AC   MF_03045;
DC   Protein; auto
TR   HAMAP; MF_03045; -; 1; level=0
XX
Names: DIS3L2
XX
ID   DI3L2
DE   RecName: Full=DIS3-like exonuclease 2;
DE            EC=3.1.13.-;
case <OC:Mammalia>
GN   Name=DIS3L2;
else case <OC:Vertebrata>
GN   Name=dis3l2;
end case
XX
case <OC:Mammalia>
CC   -!- FUNCTION: 3'-5'-exoribonuclease that specifically recognizes RNAs
CC       polyuridylated at their 3' end and mediates their degradation.
CC       Component of an exosome-independent RNA degradation pathway that
CC       mediates degradation of both mRNAs and miRNAs that have been
CC       polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4.
CC       Mediates degradation of cytoplasmic mRNAs that have been deadenylated
CC       and subsequently uridylated at their 3'. Mediates degradation of
CC       uridylated pre-let-7 miRNAs, contributing to the maintenance of
CC       embryonic stem (ES) cells. Essential for correct mitosis, and
CC       negatively regulates cell proliferation.
else case <OC:Vertebrata>
CC   -!- FUNCTION: 3'-5'-exoribonuclease that specifically recognizes RNAs
CC       polyuridylated at their 3' end and mediates their degradation.
CC       Component of an exosome-independent RNA degradation pathway that
CC       mediates degradation of both mRNAs and miRNAs that have been
CC       polyuridylated by a terminal uridylyltransferase. Essential for correct
CC       mitosis, and negatively regulates cell proliferation.
else
CC   -!- FUNCTION: 3'-5'-exoribonuclease that specifically recognizes RNAs
CC       polyuridylated at their 3' end and mediates their degradation.
CC       Component of an exosome-independent RNA degradation pathway that
CC       mediates degradation of cytoplasmic mRNAs that have been deadenylated
CC       and subsequently uridylated at their 3'.
end case
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, P-body.
case <OC:Vertebrata>
CC   -!- DOMAIN: Specifically recognizes and binds polyuridylated RNAs via 3
CC       RNA-binding regions (named U-zone 1, U-zone 2 and U-zone 3) that form
CC       an open funnel on one face of the catalytic domain, allowing RNA to
CC       navigate a path to the active site.
end case
CC   -!- SIMILARITY: Belongs to the RNR ribonuclease family. DIS3L2 subfamily.
XX
DR   PROSITE; PS01175; RIBONUCLEASE_II; 1; trigger=no
DR   Pfam; PF00773; RNB; 1; trigger=no
XX
KW   Cytoplasm
KW   Exonuclease
KW   Hydrolase
KW   Magnesium
KW   Manganese
KW   Metal-binding
KW   Nuclease
KW   RNA-binding
case <OC:Vertebrata>
KW   Cell cycle
KW   Cell division
KW   Mitosis
end case
XX
GO   GO:0005737; C:cytoplasm
GO   GO:0000932; C:P-body
GO   GO:0000175; F:3'-5'-RNA exonuclease activity
GO   GO:0000291; P:nuclear-transcribed mRNA catabolic process, exonucleolytic
GO   GO:1990074; P:polyuridylation-dependent mRNA catabolic process
case <OC:Vertebrata>
GO   GO:0010587; P:miRNA catabolic process
end case
XX
FT   From: DI3L2_MOUSE (Q8CI75)
FT   SITE            389
FT                   /note="Important for catalytic activity"
FT   Condition: D
FT   BINDING         381
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Condition: D
FT   BINDING         390
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Condition: D
XX
Size: 811-1426;
Related: None;
Template: Q8IYB7; Q8CI75; P0DM58; O14040;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.12 2023/02/07
//