AC MF_03046; DC Protein; auto TR HAMAP; MF_03046; -; 1; level=0 XX Names: ENY2_Sus1 XX case ID SUS1 DE RecName: Full=Transcription and mRNA export factor ; else case ID ENY2 DE RecName: Full=Enhancer of yellow 2 transcription factor; else ID ENY2 DE RecName: Full=Transcription and mRNA export factor ENY2; DE AltName: Full=Enhancer of yellow 2 transcription factor homolog; end case case GN Name=SUS1; else case GN Name=e(y)2; else case GN Name=ENY2; end case XX case CC -!- FUNCTION: Involved in mRNA export coupled transcription activation by CC association with both the TREX-2 and the SAGA complexes. At the CC promoters, SAGA is required for recruitment of the basal transcription CC machinery. It influences RNA polymerase II transcriptional activity CC through different activities such as TBP interaction and promoter CC selectivity, interaction with transcription activators, and chromatin CC modification through histone acetylation and deubiquitination. Within CC the SAGA complex, participates to a subcomplex required for CC deubiquitination of H2B and for the maintenance of steady-state H3 CC methylation levels. The TREX-2 complex functions in docking export- CC competent ribonucleoprotein particles (mRNPs) to the nuclear entrance CC of the nuclear pore complex (nuclear basket). TREX-2 participates in CC mRNA export and accurate chromatin positioning in the nucleus by CC tethering genes to the nuclear periphery. May also be involved in CC cytoplasmic mRNA decay by interaction with components of P-bodies. CC -!- SUBUNIT: Component of the nuclear pore complex (NPC)-associated TREX-2 CC complex (transcription and export complex 2), composed of at least CC @gn(SUS1), @gn(SAC3), @gn(THP1), @gn(SEM1), and @gn(CDC31). TREX-2 CC contains 2 @gn(SUS1) chains. The TREX-2 complex interacts with the CC nucleoporin @gn(NUP1). Component of the 1.8 MDa SAGA transcription CC coactivator-HAT complex. SAGA is built of 5 distinct domains with CC specialized functions. Within the SAGA complex, @gn(SUS1), @gn(SGF11), CC @gn(SGF73) and @gn(UBP8) form an additional subcomplex of SAGA called CC the DUB module (deubiquitination module). Interacts directly with CC @gn(THP1), @gn(SAC3), @gn(SGF11), and with the RNA polymerase II. CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm. Cytoplasm, P-body. else case CC -!- FUNCTION: Involved in mRNA export coupled transcription activation by CC association with both the TREX-2 and the SAGA complexes. The CC transcription regulatory histone acetylation (HAT) complex SAGA is a CC multiprotein complex that activates transcription by remodeling CC chromatin and mediating histone acetylation and deubiquitination. CC Within the SAGA complex, participates to a subcomplex that specifically CC deubiquitinates both histones H2A and H2B. The SAGA complex is CC recruited to specific gene promoters by activators such as @gn(MYC), CC where it is required for transcription. Required for nuclear receptor- CC mediated transactivation. The TREX-2 complex functions in docking CC export-competent ribonucleoprotein particles (mRNPs) to the nuclear CC entrance of the nuclear pore complex (nuclear basket). TREX-2 CC participates in mRNA export and accurate chromatin positioning in the CC nucleus by tethering genes to the nuclear periphery. CC -!- SUBUNIT: Component of the nuclear pore complex (NPC)-associated TREX-2 CC complex (transcription and export complex 2), composed of at least CC ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 CC contains 2 ENY2 chains. The TREX-2 complex interacts with the CC nucleoporin NUP153. Component of some SAGA transcription coactivator- CC HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, CC SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, CC ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB CC module (deubiquitination module). Interacts directly with ATXN7L3, GANP CC and with the RNA polymerase II. Interacts strongly with ATXN7L3 and CC ATXN7L3B. CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm. else case CC -!- FUNCTION: Involved in mRNA export coupled transcription activation by CC association with both the AMEX and the SAGA complexes. The SAGA complex CC is a multiprotein complex that activates transcription by remodeling CC chromatin and mediating histone acetylation and deubiquitination. CC Within the SAGA complex, participates to a subcomplex that specifically CC deubiquitinates histone H2B. The SAGA complex is recruited to specific CC gene promoters by activators, where it is required for transcription. CC Required for nuclear receptor-mediated transactivation. Involved in CC transcription elongation by recruiting the THO complex onto nascent CC mRNA. The AMEX complex functions in docking export-competent CC ribonucleoprotein particles (mRNPs) to the nuclear entrance of the CC nuclear pore complex (nuclear basket). AMEX participates in mRNA export CC and accurate chromatin positioning in the nucleus by tethering genes to CC the nuclear periphery. CC -!- SUBUNIT: Component of the nuclear pore complex (NPC)-associated AMEX CC complex (anchoring and mRNA export complex), composed of at least e(y)2 CC and xmas-2. Component of the SAGA transcription coactivator-HAT CC complexes, at least composed of Ada2b, e(y)2, Pcaf/Gcn5, Taf10 and CC Nipped-A/Trrap. Within the SAGA complex, e(y)2, Sgf11, and not/nonstop CC form an additional subcomplex of SAGA called the DUB module CC (deubiquitination module). Component of the THO complex, composed of at CC least e(y)2, HPR1, THO2, THOC5, THOC6 and THOC7. Interacts with e(y)1. CC Interacts with su(Hw) (via zinc fingers). Interacts with xmas-2; CC required for localization to the nuclear periphery. Interacts with the CC nuclear pore complex (NPC). CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm. Cytoplasm. else CC -!- FUNCTION: Involved in mRNA export coupled transcription activation by CC association with both the TREX-2 and the SAGA complexes. The CC transcription regulatory histone acetylation (HAT) complex SAGA is a CC multiprotein complex that activates transcription by remodeling CC chromatin and mediating histone acetylation and deubiquitination. CC Within the SAGA complex, participates to a subcomplex that specifically CC deubiquitinates histones. The SAGA complex is recruited to specific CC gene promoters by activators, where it is required for transcription. CC The TREX-2 complex functions in docking export-competent CC ribonucleoprotein particles (mRNPs) to the nuclear entrance of the CC nuclear pore complex (nuclear basket). TREX-2 participates in mRNA CC export and accurate chromatin positioning in the nucleus by tethering CC genes to the nuclear periphery. CC -!- SUBUNIT: Component of the nuclear pore complex (NPC)-associated TREX-2 CC complex (transcription and export complex 2). Component of the SAGA CC transcription coactivator-HAT complex. Within the SAGA complex, CC participates to a subcomplex of SAGA called the DUB module CC (deubiquitination module). CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm. end case CC -!- SIMILARITY: Belongs to the ENY2 family. XX KW Activator KW Chromatin regulator KW mRNA transport KW Nucleus KW Transcription KW Transcription regulation KW Transport KW Protein transport KW Translocation case or KW Cytoplasm end case XX case GO GO:0043035; F:chromatin insulator sequence binding end case case or GO GO:0030374; F:nuclear receptor coactivator activity end case case or GO GO:0005737; C:cytoplasm end case GO GO:0003713; F:transcription coactivator activity GO GO:0006368; P:transcription elongation by RNA polymerase II GO GO:0006406; P:mRNA export from nucleus GO GO:0045893; P:positive regulation of DNA-templated transcription GO GO:0016578; P:histone deubiquitination GO GO:0000124; C:SAGA complex GO GO:0071819; C:DUBm complex GO GO:0070390; C:transcription export complex 2 GO GO:0005634; C:nucleus GO GO:0005643; C:nuclear pore XX FT None XX Size: 87-159; Related: None; Template: Q9NPA8; Q9VYX1; Q6WNK7; Scope: Eukaryota Fusion: Nter: None Cter: None Duplicate: in SALSA Plasmid: None Comments: None XX # Revision 1.15 2023/02/07 //