AC MF_03047; DC Protein; auto TR HAMAP; MF_03047; -; 1; level=0 XX Names: Sgf11 XX case ID AT7L3 DE RecName: Full=Ataxin-7-like protein 3; DE AltName: Full=SAGA-associated factor 11 homolog; else case ID SGF11 DE RecName: Full=SAGA-associated factor 11; else ID SGF11 DE RecName: Full=SAGA-associated factor 11 homolog; end case case GN Name=ATXN7L3; else case GN Name=SGF11; else case GN Name=Sgf11; end case XX case CC -!- FUNCTION: Component of the transcription regulatory histone acetylation CC (HAT) complex SAGA, a multiprotein complex that activates transcription CC by remodeling chromatin and mediating histone acetylation and CC deubiquitination. Within the SAGA complex, participates in a subcomplex CC that specifically deubiquitinates both histones H2A and H2B. The SAGA CC complex is recruited to specific gene promoters by activators such as CC @gn(MYC), where it is required for transcription. Required for nuclear CC receptor-mediated transactivation. Within the complex, it is required CC to recruit USP22 and ENY2 into the SAGA complex. Regulates H2B CC monoubiquitination (H2Bub1) levels. Affects subcellular distribution of CC ENY2, USP22 and ATXN7L3B. CC -!- SUBUNIT: Component of some SAGA transcription coactivator-HAT CC complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, CC TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, CC and USP22 form an additional subcomplex of SAGA called the DUB module CC (deubiquitination module). Interacts directly with ENY2 and USP22. CC -!- DOMAIN: The C-terminal SGF11-type zinc-finger domain together with the CC C-terminal catalytic domain of @gn(USP22) forms the 'catalytic lobe' of CC the SAGA deubiquitination module. else case CC -!- FUNCTION: Component of the transcription regulatory histone acetylation CC (HAT) complex SAGA, a multiprotein complex that activates transcription CC by remodeling chromatin and mediating histone acetylation and CC deubiquitination. Within the SAGA complex, participates in a subcomplex CC that specifically deubiquitinates histone H2B. The SAGA complex is CC recruited to specific gene promoters by activators, where it is CC required for transcription. Required for nuclear receptor-mediated CC transactivation. Binds independently on SAGA to promoters in an RNA- CC dependent manner. Binds to mRNA and is essential for total mRNA export CC from the nucleus. Required to counteract heterochromatin silencing. CC Controls the development of neuronal connectivity in visual system by CC being required for accurate axon targeting in the optic lobe. Required CC for expression of ecdysone-induced genes such as br/broad. CC -!- SUBUNIT: Component of some SAGA transcription coactivator-HAT CC complexes, at least composed of Ada2b, not/nonstop, Pcaf/Gcn5, Sgf11 CC and Spt3. Within the SAGA complex, Sgf11, e(y)2, and not/nonstop form CC an additional subcomplex of SAGA called the DUB module CC (deubiquitination module). Interacts directly with not/nonstop. CC Interacts with the AMEX complex component xmas-2. Interacts with Cbp80; CC important for promoter recruitment of Sgf11 that is not associated with CC the DUB module. CC -!- DOMAIN: The C-terminal SGF11-type zinc-finger domain together with the CC C-terminal catalytic domain of not/nonstop forms the 'catalytic lobe' CC of the SAGA deubiquitination module. else case CC -!- FUNCTION: Functions as component of the transcription regulatory CC histone acetylation (HAT) complex SAGA. At the promoters, SAGA is CC required for recruitment of the basal transcription machinery. It CC influences RNA polymerase II transcriptional activity through different CC activities such as TBP interaction and promoter selectivity, CC interaction with transcription activators, and chromatin modification CC through histone acetylation and deubiquitination. SAGA acetylates CC nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac CC and H3K23ac). SAGA interacts with DNA via upstream activating sequences CC (UASs). Involved in transcriptional regulation of a subset of SAGA- CC regulated genes. Within the SAGA complex, participates in a subcomplex, CC that specifically deubiquitinates histones H2B. CC -!- SUBUNIT: Component of the 1.8 MDa SAGA transcription coactivator-HAT CC complex. SAGA is built of 5 distinct domains with specialized CC functions. Within the SAGA complex, @gn(SUS1), @gn(SGF11), @gn(SGF73) CC and @gn(UBP8) form an additional subcomplex of SAGA called the DUB CC module (deubiquitination module). Interacts directly with @gn(SGF73), CC @gn(SUS1) and @gn(UBP8). CC -!- DOMAIN: The C-terminal SGF11-type zinc-finger domain together with the CC C-terminal catalytic domain of @gn(UBP8) forms the 'catalytic lobe' of CC the SAGA deubiquitination module. else CC -!- FUNCTION: Component of the transcription regulatory histone acetylation CC (HAT) complex SAGA, a multiprotein complex that activates transcription CC by remodeling chromatin and mediating histone acetylation and CC deubiquitination. Within the SAGA complex, participates in a subcomplex CC that specifically deubiquitinates histone H2B. The SAGA complex is CC recruited to specific gene promoters by activators, where it is CC required for transcription. CC -!- SUBUNIT: Component of some SAGA transcription coactivator-HAT CC complexes. Within the SAGA complex, participates to a subcomplex of CC SAGA called the DUB module (deubiquitination module). CC -!- DOMAIN: The C-terminal SGF11-type zinc-finger domain forms part of the CC 'catalytic lobe' of the SAGA deubiquitination module. end case case CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm. Cytoplasm. Note=Localizes CC to nuclear periphery, in contact with the nuclear pore complex (NPC). else CC -!- SUBCELLULAR LOCATION: Nucleus. end case CC -!- DOMAIN: The long N-terminal helix forms part of the 'assembly lobe' of CC the SAGA deubiquitination module. CC -!- SIMILARITY: Belongs to the SGF11 family. XX DR Pfam; PF08313; SCA7; 0-1; trigger=no DR Pfam; PF08209; Sgf11; 1; trigger=no case DR PROSITE; PS51505; SCA7; 1; trigger=yes end case XX KW Activator KW Chromatin regulator KW Metal-binding KW Nucleus KW Transcription KW Transcription regulation KW Zinc KW Zinc-finger case KW Cytoplasm KW mRNA transport KW Transport end case XX case or GO GO:0030374; F:nuclear receptor coactivator activity end case case GO GO:0005737; C:cytoplasm GO GO:0006406; P:mRNA export from nucleus GO GO:0005643; C:nuclear pore end case GO GO:0003713; F:transcription coactivator activity GO GO:0008270; F:zinc ion binding GO GO:0045893; P:positive regulation of DNA-templated transcription GO GO:0016578; P:histone deubiquitination GO GO:0000124; C:SAGA complex GO GO:0071819; C:DUBm complex GO GO:0005634; C:nucleus XX FT From: SGF11_YEAST (Q03067) FT ZN_FING 71..92 FT /note="SGF11-type" FT Condition: [YCIFL]-x-C-x(2)-C-x(11)-H-x(3)-C XX Size: 90-374; Related: None; Template: Q03067; Q14CW9; Q9VVR6; Scope: Eukaryota Fusion: Nter: None Cter: None Duplicate: in DROGR, DROWI Plasmid: None Comments: None XX # Revision 1.13 2022/06/29 //