AC   MF_03050;
DC   Protein; auto
TR   HAMAP; MF_03050; -; 1; level=0
XX
Names: MOCOS
XX
ID   MOCOS
DE   RecName: Full=Molybdenum cofactor sulfurase;
DE            Short=MCS;
DE            Short=MOS;
DE            Short=MoCo sulfurase;
DE            EC=2.8.1.9;
DE   AltName: Full=Molybdenum cofactor sulfurtransferase;
case <OC:Insecta>
DE   + AltName: Full=Protein maroon-like;
DE            Short=Ma-l;
end case
case <OC:Vertebrata>
GN   Name=MOCOS;
end case
case <OC:Insecta>
GN   Name=mal;
end case
case <OC:Pezizomycotina>
GN   Name=hxB;
end case
XX
CC   -!- FUNCTION: Sulfurates the molybdenum cofactor. Sulfation of molybdenum
CC       is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase
CC       (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and
CC       1 sulfur atom in active form.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=AH2 + L-cysteine + Mo-molybdopterin = A + H2O + L-alanine +
CC         thio-Mo-molybdopterin; Xref=Rhea:RHEA:42636, ChEBI:CHEBI:13193,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:17499, ChEBI:CHEBI:35235,
CC         ChEBI:CHEBI:57972, ChEBI:CHEBI:71302, ChEBI:CHEBI:82685; EC=2.8.1.9;
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC   -!- SIMILARITY: Belongs to the class-V pyridoxal-phosphate-dependent
CC       aminotransferase family. MOCOS subfamily.
XX
DR   PROSITE; PS00595; AA_TRANSFER_CLASS_5; 1; trigger=no
DR   PROSITE; PS51340; MOSC; 1; trigger=yes
DR   Pfam; PF00266; Aminotran_5; 1; trigger=no
DR   Pfam; PF03473; MOSC; 1; trigger=no
DR   Pfam; PF03476; MOSC_N; 1; trigger=no
XX
KW   Molybdenum cofactor biosynthesis
KW   Pyridoxal phosphate
KW   Transferase
XX
GO   GO:0016829; F:lyase activity
GO   GO:0008265; F:Mo-molybdopterin cofactor sulfurase activity
GO   GO:0030151; F:molybdenum ion binding
GO   GO:0030170; F:pyridoxal phosphate binding
GO   GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process
XX
FT   From: MOCOS_HUMAN (Q96EN8)
FT   ACT_SITE        424
FT   Condition: C
FT   MOD_RES         264
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT   Condition: K
XX
Size: 707-1007;
Related: None;
Template: Q96EN8; Q9N0E7; Q9VRA2; Q9C5X8; Q9UV64;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: in AEDAE, CULQU
Plasmid: None
Comments: None
XX
# Revision 1.10 2019/11/20
//