AC   MF_03051;
DC   Protein; auto
TR   HAMAP; MF_03051; -; 1; level=0
XX
Names: MOCS2A
XX
ID   MOC2A
DE   RecName: Full=Molybdopterin synthase sulfur carrier subunit;
DE   AltName: Full=Molybdenum cofactor synthesis protein 2 small subunit;
DE   AltName: Full=Molybdenum cofactor synthesis protein 2A;
DE            Short=MOCS2A;
DE   AltName: Full=Sulfur carrier protein MOCS2A;
case <OC:Pezizomycotina>
DE   + AltName: Full=Common component for nitrate reductase and xanthine dehydrogenase protein G;
end case
case <OC:Pezizomycotina>
GN   Name=cnxG;
else case <OC:Vertebrata>
GN   Name=MOCS2;
else case <OC:Insecta>
GN   Name=Mocs2;
end case
XX
case <OC:Fungi>
CC   -!- FUNCTION: Acts as a sulfur carrier required for molybdopterin
CC       biosynthesis. Component of the molybdopterin synthase complex that
CC       catalyzes the conversion of precursor Z into molybdopterin by mediating
CC       the incorporation of 2 sulfur atoms into precursor Z to generate a
CC       dithiolene group. In the complex, serves as sulfur donor by being
CC       thiocarboxylated (-COSH) at its C-terminus by @gn(UBA4). After
CC       interaction with MOCS2B, the sulfur is then transferred to precursor Z
CC       to form molybdopterin.
else case <OC:Metazoa> or <OC:Viridiplantae>
CC   -!- FUNCTION: Acts as a sulfur carrier required for molybdopterin
CC       biosynthesis. Component of the molybdopterin synthase complex that
CC       catalyzes the conversion of precursor Z into molybdopterin by mediating
CC       the incorporation of 2 sulfur atoms into precursor Z to generate a
CC       dithiolene group. In the complex, serves as sulfur donor by being
CC       thiocarboxylated (-COSH) at its C-terminus by @gn(MOCS3). After
CC       interaction with MOCS2B, the sulfur is then transferred to precursor Z
CC       to form molybdopterin.
else
CC   -!- FUNCTION: Acts as a sulfur carrier required for molybdopterin
CC       biosynthesis. Component of the molybdopterin synthase complex that
CC       catalyzes the conversion of precursor Z into molybdopterin by mediating
CC       the incorporation of 2 sulfur atoms into precursor Z to generate a
CC       dithiolene group. In the complex, serves as sulfur donor by being
CC       thiocarboxylated (-COSH) at its C-terminus by by the MOCS3 homolog.
CC       After interaction with MOCS2B, the sulfur is then transferred to
CC       precursor Z to form molybdopterin.
end case
CC   -!- PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis.
CC   -!- SUBUNIT: Heterotetramer; composed of 2 small (MOCS2A) and 2 large
CC       (MOCS2B) subunits.
case <OC:Vertebrata>
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol.
else
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
end case
case <OC:Fungi>
CC   -!- PTM: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-
CC       adenylated (-COAMP) via the hesA/moeB/thiF part of @gn(UBA4), then
CC       thiocarboxylated (-COSH) via the rhodanese domain of @gn(UBA4).
else case <OC:Metazoa> or <OC:Viridiplantae>
CC   -!- PTM: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-
CC       adenylated (-COAMP) via the hesA/moeB/thiF part of @gn(MOCS3), then
CC       thiocarboxylated (-COSH) via the rhodanese domain of @gn(MOCS3).
else
CC   -!- PTM: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-
CC       adenylated (-COAMP) via the hesA/moeB/thiF part of the MOCS3 homolog,
CC       then thiocarboxylated (-COSH) via the rhodanese domain of the MOCS3
CC       homolog.
end case
case <OC:Mammalia>
CC   -!- MISCELLANEOUS: This protein is produced by a bicistronic gene which
CC       also produces the large subunit (MOCS2B) from an overlapping reading
CC       frame.
else case <OC:Vertebrata> or <OC:Insecta>
CC   -!- MISCELLANEOUS: This protein is produced by a bicistronic gene which
CC       also produces the large subunit (MOCS2B).
end case
CC   -!- SIMILARITY: Belongs to the MoaD family. MOCS2A subfamily.
XX
DR   Pfam; PF02597; ThiS; 1; trigger=no
DR   NCBIfam; TIGR01682; moaD; 1; trigger=no
DR   NCBIfam; TIGR01687; moaD_arch; 1; trigger=no
XX
KW   Cytoplasm
KW   Molybdenum cofactor biosynthesis
KW   Nucleotide-binding
case <FTTag:phospho>
KW   Phosphoprotein
end case
XX
GO   GO:0030366; F:molybdopterin synthase activity
GO   GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process
GO   GO:0019008; C:molybdopterin synthase complex
case <OC:Vertebrata>
GO   GO:0005829; C:cytosol
else
GO   GO:0005737; C:cytoplasm
end case
XX
FT   From: MOC2A_HUMAN (O96033)
FT   MOD_RES         88
FT                   /note="1-thioglycine; alternate"
FT   Condition: G
FT   MOD_RES         88
FT                   /note="Glycyl adenylate; alternate"
FT   Tag: phospho; Condition: G
XX
Size: 83-195;
Related: None;
Template: O96033;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.7 2023/06/01
//