AC   MF_03052;
DC   Protein; auto
TR   HAMAP; MF_03052; -; 1; level=0
XX
Names: MOC2B
XX
ID   MOC2B
DE   RecName: Full=Molybdopterin synthase catalytic subunit;
DE            EC=2.8.1.12;
DE   AltName: Full=Molybdenum cofactor synthesis protein 2 large subunit;
DE   AltName: Full=Molybdenum cofactor synthesis protein 2B;
DE            Short=MOCS2B;
case <OC:Pezizomycotina>
DE   + AltName: Full=Common component for nitrate reductase and xanthine dehydrogenase protein H;
end case
case <OC:Pezizomycotina>
GN   Name=cnxH;
else case <OC:Vertebrata>
GN   Name=MOCS2;
else case <OC:Insecta>
GN   Name=Mocs2;
end case
XX
CC   -!- FUNCTION: Catalytic subunit of the molybdopterin synthase complex, a
CC       complex that catalyzes the conversion of precursor Z into
CC       molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms
CC       from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene
CC       group.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal
CC         Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O = 2
CC         [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly +
CC         4 H(+) + molybdopterin; Xref=Rhea:RHEA:26333, Rhea:RHEA-COMP:12160,
CC         Rhea:RHEA-COMP:12202, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:58698, ChEBI:CHEBI:59648, ChEBI:CHEBI:90619,
CC         ChEBI:CHEBI:90778; EC=2.8.1.12;
CC   -!- PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis.
CC   -!- SUBUNIT: Heterotetramer; composed of 2 small (MOCS2A) and 2 large
CC       (MOCS2B) subunits.
case <OC:Vertebrata>
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol.
else
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
end case
case <OC:Mammalia>
CC   -!- MISCELLANEOUS: This protein is produced by a bicistronic gene which
CC       also produces the small subunit (MOCS2A) from an overlapping reading
CC       frame.
else case <OC:Vertebrata> or <OC:Insecta>
CC   -!- MISCELLANEOUS: This protein is produced by a bicistronic gene which
CC       also produces the large subunit (MOCS2A).
end case
CC   -!- SIMILARITY: Belongs to the MoaE family. MOCS2B subfamily.
XX
DR   Pfam; PF02391; MoaE; 1; trigger=no
XX
KW   Cytoplasm
KW   Molybdenum cofactor biosynthesis
KW   Transferase
XX
GO   GO:0030366; F:molybdopterin synthase activity
GO   GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process
GO   GO:0019008; C:molybdopterin synthase complex
case not <OC:Vertebrata>
GO   GO:0005737; C:cytoplasm
else
GO   GO:0005829; C:cytosol
end case
XX
FT   From: MOC2B_HUMAN (O96007)
FT   BINDING         143..144
FT                   /ligand="substrate"
FT   Condition: [HF]-R
FT   BINDING         166..168
FT                   /ligand="substrate"
FT   Condition: K-x-E
FT   BINDING         159
FT                   /ligand="substrate"
FT   Condition: K
XX
Size: 154-372;
Related: None;
Template: O96007; Q9Y8C1;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: in AEDAE
Plasmid: None
Comments: None
XX
# Revision 1.8 2022/05/14
//