AC   MF_03054;
DC   Protein; auto
TR   HAMAP; MF_03054; -; 1; level=0
XX
Names: CTU2
XX
ID   CTU2
DE   RecName: Full=Cytoplasmic tRNA 2-thiolation protein 2;
case <OC:Caenorhabditis>
DE   + AltName: Full=Thiolation of uridine in tRNA protein 2;
else case <OC:Saccharomyces>
DE   + AltName: Full=Thiolation of uridine in cytoplasmic tRNA protein 2;
DE   + AltName: Full=Needs CLA4 to survive protein 2;
end case
case <OC:Vertebrata>
GN   Name=CTU2; Synonyms=NCS2;
else case <OC:Caenorhabditis>
GN   Name=tut-2;
else case <OC:Saccharomyces>
GN   Name=NCS2; Synonyms=CTU2, TUC2;
else case <OC:Fungi>
GN   Name=NCS2; Synonyms=CTU2;
end case
XX
case <OC:Vertebrata>
CC   -!- FUNCTION: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA
CC       wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by
CC       forming a heterodimer with @gn(CTU1)/@gn(ATPBD3) that ligates sulfur
CC       from thiocarboxylated @gn(URM1) onto the uridine of tRNAs at wobble
CC       position.
else case <OC:Caenorhabditis>
CC   -!- FUNCTION: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA
CC       wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by
CC       forming a heterodimer with tut-1/ctu-1 that ligates sulfur from
CC       thiocarboxylated urm-1 onto the uridine of tRNAs at wobble position.
else case <OC:Fungi>
CC   -!- FUNCTION: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA
CC       wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by
CC       forming a heterodimer with @gn(NCS6) that ligates sulfur from
CC       thiocarboxylated @gn(URM1) onto the uridine of tRNAs at wobble
CC       position. Prior mcm(5) tRNA modification by the elongator complex is
CC       required for 2-thiolation. May also be involved in protein urmylation.
else
CC   -!- FUNCTION: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA
CC       wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by
CC       forming a heterodimer with @gn(NCS6)/@gn(CTU1) that ligates sulfur from
CC       thiocarboxylated @gn(URM1) onto the uridine of tRNAs at wobble
CC       position.
end case
CC   -!- PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA
CC       biosynthesis.
case <OC:Mammalia>
CC   -!- SUBUNIT: Component of a complex at least composed of URM1, CTU2/NCS2
CC       and CTU1/ATPBD3.
else case <OC:Saccharomyces>
CC   -!- SUBUNIT: Interacts with NCS6 and URM1. May act by forming a heterodimer
CC       with NCS6.
end case
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the CTU2/NCS2 family.
XX
DR   Pfam; PF01171; ATP_bind_3; 1; trigger=no
XX
KW   Cytoplasm
KW   tRNA processing
XX
GO   GO:0016779; F:nucleotidyltransferase activity
GO   GO:0002098; P:tRNA wobble uridine modification
GO   GO:0032447; P:protein urmylation
GO   GO:0034227; P:tRNA thio-modification
GO   GO:0005737; C:cytoplasm
XX
FT   None
XX
Size: 325-687;
Related: None;
Template: Q2VPK5; P53923; Q9UUC7;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: in XENLA
Plasmid: None
Comments: None
XX
# Revision 1.5 2019/11/20
//