AC   MF_03060;
DC   Protein; auto
TR   HAMAP; MF_03060; -; 1; level=0
XX
Names: Draxin
XX
ID   DRAXI
DE   RecName: Full=Draxin;
DE   AltName: Full=Dorsal inhibitory axon guidance protein;
DE   AltName: Full=Dorsal repulsive axon guidance protein;
GN   Name=DRAXIN;
XX
case <OC:Mammalia>
CC   -!- FUNCTION: Chemorepulsive axon guidance protein required for the
CC       development of spinal cord and forebrain commissures. Acts as a
CC       chemorepulsive guidance protein for commissural axons during
CC       development. Able to inhibit or repel neurite outgrowth from dorsal
CC       spinal cord. Inhibits the stabilization of cytosolic beta-catenin
CC       (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist
CC       of Wnt signaling pathway.
CC   -!- SUBUNIT: Interacts with LRP6.
else
CC   -!- FUNCTION: Chemorepulsive axon guidance protein required for the
CC       development of spinal cord and forebrain commissures. Acts as a
CC       chemorepulsive guidance protein for commissural axons during
CC       development. Able to inhibit or repel neurite outgrowth from dorsal
CC       spinal cord.
end case
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the draxin family.
XX
DR   PROSITE; PS00001; ASN_GLYCOSYLATION; 0-10; trigger=yes
DR   General; Signal; -; 1; trigger=yes
XX
KW   Developmental protein
KW   Secreted
case <OC:Mammalia>
KW   Wnt signaling pathway
end case
XX
GO   GO:0005576; C:extracellular region
GO   GO:0007411; P:axon guidance
GO   GO:0021516; P:dorsal spinal cord development
GO   GO:0021528; P:commissural neuron differentiation in spinal cord
GO   GO:0030900; P:forebrain development
case <OC:Mammalia>
GO   GO:0090090; P:negative regulation of canonical Wnt signaling pathway
end case
XX
FT   None
XX
Size: 326-382;
Related: None;
Template: Q6PAL1; B6ZI38;
Scope:
 Eukaryota; Vertebrata
Fusion:
 Nter: None
 Cter: None
Duplicate: in SALSA
Plasmid: None
Comments: None
XX
# Revision 1.6 2019/11/20
//