AC   MF_03061;
DC   Protein; auto
c?   <OC:Eukaryota>
TR   HAMAP; MF_00054_B; -; 1; level=0
XX
Names: mEF-G_1
XX
ID   EFGM
DE   RecName: Full=Elongation factor G, mitochondrial;
DE            Short=EF-Gmt;
DE   AltName: Full=Elongation factor G 1, mitochondrial;
DE            Short=mEF-G 1;
DE   AltName: Full=Elongation factor G1;
case <OC:Vertebrata>
GN   Name=GFM1; Synonyms=EFG1;
else case <OC:Fungi>
GN   Name=MEF1;
end case
XX
case <OC:Vertebrata>
CC   -!- FUNCTION: Mitochondrial GTPase that catalyzes the GTP-dependent
CC       ribosomal translocation step during translation elongation. During this
CC       step, the ribosome changes from the pre-translocational (PRE) to the
CC       post-translocational (POST) state as the newly formed A-site-bound
CC       peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E
CC       sites, respectively. Catalyzes the coordinated movement of the two tRNA
CC       molecules, the mRNA and conformational changes in the ribosome. Does
CC       not mediate the disassembly of ribosomes from messenger RNA at the
CC       termination of mitochondrial protein biosynthesis.
else
CC   -!- FUNCTION: Mitochondrial GTPase that catalyzes the GTP-dependent
CC       ribosomal translocation step during translation elongation. During this
CC       step, the ribosome changes from the pre-translocational (PRE) to the
CC       post-translocational (POST) state as the newly formed A-site-bound
CC       peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E
CC       sites, respectively. Catalyzes the coordinated movement of the two tRNA
CC       molecules, the mRNA and conformational changes in the ribosome.
end case
CC   -!- PATHWAY: Protein biosynthesis; polypeptide chain elongation.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion.
case <OC:Saccharomyces>
CC   -!- PTM: The precursor is processed in two steps involving mitochondrial
CC       intermediate peptidase (MIP) and mitochondrial processing peptidase
CC       (MPP).
end case
case not <AnyFeature:TransitM>
CC   -!- MISCELLANEOUS: This protein may be expected to contain an N-terminal
CC       transit peptide but none has been predicted.
end case
CC   -!- SIMILARITY: Belongs to the GTP-binding elongation factor family. EF-
CC       G/EF-2 subfamily.
XX
DR   PROSITE; PS00301; G_TR_1; 1; trigger=no
DR   Pfam; PF00679; EFG_C; 1; trigger=no
DR   Pfam; PF03764; EFG_IV; 1; trigger=no
DR   Pfam; PF00009; GTP_EFTU; 1; trigger=no
DR   Pfam; PF03144; GTP_EFTU_D2; 1; trigger=no
DR   PRINTS; PR00315; ELONGATNFCT; 1; trigger=no
DR   NCBIfam; TIGR00484; EF-G; 1; trigger=no
DR   NCBIfam; TIGR00231; small_GTP; 1; trigger=no
DR   General; TransitM; -; 0-1; trigger=yes
XX
KW   Elongation factor
KW   GTP-binding
KW   Mitochondrion
KW   Nucleotide-binding
KW   Protein biosynthesis
XX
GO   GO:0003746; F:translation elongation factor activity
GO   GO:0003924; F:GTPase activity
GO   GO:0005525; F:GTP binding
GO   GO:0070125; P:mitochondrial translational elongation
GO   GO:0005739; C:mitochondrion
XX
FT   From: EFGM_HUMAN (Q96RP9)
FT   BINDING         53..60
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT   Condition: [AS]-H-[IV]-D-[AS]-G-K-T
FT   BINDING         120..124
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT   Condition: D-T-P-G-H
FT   BINDING         174..177
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT   Condition: N-K-x-D
XX
Size: 669-872;
Related: MF_03063!;
Template: Q96RP9; P25039;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.10 2023/06/01
//