AC   MF_03064;
DC   Protein; auto
TR   HAMAP; MF_03064; -; 1; level=0
XX
Names: SLC25A38
XX
ID   S2538
case <OC:Vertebrata>
DE   RecName: Full=Mitochondrial glycine transporter;
DE   AltName: Full=Solute carrier family 25 member 38;
GN   Name=SLC25A38;
else
DE   RecName: Full=Mitochondrial glycine transporter;
DE   AltName: Full=Solute carrier family 25 member 38 homolog;
end case
XX
case <OC:Vertebrata>
CC   -!- FUNCTION: Mitochondrial glycine transporter that imports glycine into
CC       the mitochondrial matrix. Plays an important role in providing glycine
CC       for the first enzymatic step in heme biosynthesis, the condensation of
CC       glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the
CC       miochondrial matrix. Required during erythropoiesis.
else
CC   -!- FUNCTION: Mitochondrial glycine transporter that imports glycine into
CC       the mitochondrial matrix. Plays an important role in providing glycine
CC       for the first enzymatic step in heme biosynthesis, the condensation of
CC       glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the
CC       miochondrial matrix.
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glycine(in) = glycine(out); Xref=Rhea:RHEA:70715,
CC         ChEBI:CHEBI:57305;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       SLC25A38 subfamily.
XX
DR   PROSITE; PS50920; SOLCAR; 3; trigger=yes
DR   Pfam; PF00153; Mito_carr; 3; trigger=no
DR   PRINTS; PR00926; MITOCARRIER; 1; trigger=no
DR   General; Transmembrane; -; 0-6; trigger=no
XX
KW   Membrane
KW   Mitochondrion
KW   Mitochondrion inner membrane
KW   Repeat
KW   Transmembrane
KW   Transmembrane helix
KW   Transport
XX
GO   GO:0015187; F:glycine transmembrane transporter activity
GO   GO:1904983; P:glycine import into mitochondrion
case <OC:Vertebrata>
GO   GO:0030218; P:erythrocyte differentiation
end case
GO   GO:0016020; C:membrane
GO   GO:0005743; C:mitochondrial inner membrane
XX
FT   From: S2538_HUMAN (Q96DW6)
FT   TRANSMEM        31..56
FT                   /note="Helical; Name=1"
FT   TRANSMEM        89..115
FT                   /note="Helical; Name=2"
FT   TRANSMEM        127..152
FT                   /note="Helical; Name=3"
FT   TRANSMEM        180..203
FT                   /note="Helical; Name=4"
FT   TRANSMEM        219..245
FT                   /note="Helical; Name=5"
FT   TRANSMEM        274..292
FT                   /note="Helical; Name=6"
XX
Size: 287-362;
Related: None;
Template: Q96DW6; Q07534;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: in DANRE
Plasmid: None
Comments: None
XX
# Revision 1.11 2022/09/29
//