AC   MF_03068;
DC   Protein; auto
TR   HAMAP; MF_03068; -; 1; level=0
XX
Names: DHX29
XX
ID   DHX29
case <OC:Mammalia>
DE   RecName: Full=ATP-dependent RNA helicase DHX29;
DE            EC=3.6.4.13;
DE   AltName: Full=DEAH box protein 29;
else
DE   RecName: Full=ATP-dependent RNA helicase <gene_name>;
DE            EC=3.6.4.13;
DE   AltName: Full=DEAH box protein 29;
end case
GN   Name=DHX29;
XX
CC   -!- FUNCTION: ATP-binding RNA helicase involved in translation initiation.
CC       Part of the 43S pre-initiation complex that is required for efficient
CC       initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by
CC       promoting efficient NTPase-dependent 48S complex formation.
CC       Specifically binds to the 40S ribosome near the mRNA entrance. Does not
CC       possess a processive helicase activity.
case <OC:Mammalia>
CC   -!- SUBUNIT: Part of the 43S pre-initiation complex (PIC) that contains at
CC       least Met-tRNA, EIF1, EIF1A (EIF1AX or EIF1AY), EIF2S1, EIF2S2, EIF2S3,
CC       EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J,
CC       EIF3K, EIF3L, EIF3M, DHX29 and the 40S ribosomal subunit.
else
CC   -!- SUBUNIT: Part of the 43S pre-initiation complex (PIC).
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
XX
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1; trigger=no
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1; trigger=yes
DR   PROSITE; PS51194; HELICASE_CTER; 1; trigger=yes
DR   General; Coiled_coil; -; 0-unlimited; trigger=yes
XX
KW   ATP-binding
KW   Cytoplasm
KW   Helicase
KW   Hydrolase
KW   Initiation factor
KW   Nucleotide-binding
KW   Protein biosynthesis
XX
GO   GO:0005524; F:ATP binding
GO   GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO   GO:0003724; F:RNA helicase activity
GO   GO:0045948; P:positive regulation of translational initiation
XX
FT   None
XX
Size: 1300-1400;
Related: None;
Template: Q7Z478;
Scope:
 Eukaryota; Vertebrata
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.4 2019/11/20
//