AC   MF_03070;
DC   Protein; auto
TR   HAMAP; MF_03070; -; 1; level=0
XX
Names: SCARA5
XX
ID   SCAR5
DE   RecName: Full=Scavenger receptor class A member 5;
GN   Name=SCARA5;
XX
case <OC:Mammalia>
CC   -!- FUNCTION: Ferritin receptor that mediates non-transferrin-dependent
CC       delivery of iron. Mediates cellular uptake of ferritin-bound iron by
CC       stimulating ferritin endocytosis from the cell surface with consequent
CC       iron delivery within the cell. Delivery of iron to cells by ferritin is
CC       required for the development of specific cell types, suggesting the
CC       existence of cell type-specific mechanisms of iron traffic in
CC       organogenesis, which alternatively utilize transferrin or non-
CC       transferrin iron delivery pathways. Ferritin mediates iron uptake in
CC       capsule cells of the developing kidney. Binds preferrentially ferritin
CC       light chain (FTL) compared to heavy chain (FTH1).
else
CC   -!- FUNCTION: Ferritin receptor that mediates non-transferrin-dependent
CC       delivery of iron. Mediates cellular uptake of ferritin-bound iron by
CC       stimulating ferritin endocytosis from the cell surface with consequent
CC       iron delivery within the cell. Delivery of iron to cells by ferritin is
CC       required for the development of specific cell types, suggesting the
CC       existence of cell type-specific mechanisms of iron traffic in
CC       organogenesis, which alternatively utilize transferrin or non-
CC       transferrin iron delivery pathways.
end case
CC   -!- SUBUNIT: Homotrimer.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the SCARA5 family.
XX
DR   PROSITE; PS00420; SRCR_1; 1; trigger=no
DR   PROSITE; PS50287; SRCR_2; 1; trigger=yes
DR   Pfam; PF01391; Collagen; 1; trigger=yes
DR   General; Coiled_coil; -; 0-unlimited; trigger=yes
case <OC:Homo>
DR   General; N_glycosylation; NetNGlyc; 0-unlimited; trigger=yes
else
DR   PROSITE; PS00001; ASN_GLYCOSYLATION; 0-unlimited; trigger=yes
end case
XX
KW   Cell membrane
KW   Ion transport
KW   Iron
KW   Iron transport
KW   Membrane
KW   Receptor
KW   Signal-anchor
KW   Transmembrane
KW   Transmembrane helix
KW   Transport
XX
GO   GO:0016020; C:membrane
GO   GO:0005886; C:plasma membrane
GO   GO:0070287; F:ferritin receptor activity
GO   GO:0006879; P:intracellular iron ion homeostasis
GO   GO:0034755; P:iron ion transmembrane transport
GO   GO:0006897; P:endocytosis
XX
FT   From: SCAR5_MOUSE (Q8K299)
FT   TOPO_DOM        Nter..60
FT                   /note="Cytoplasmic"
FT   TRANSMEM        61..81
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT   TOPO_DOM        82..Cter
FT                   /note="Extracellular"
XX
Size: 491-499;
Related: None;
Template: Q8K299;
Scope:
 Eukaryota; Vertebrata
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.5 2023/02/07
//