AC   MF_03100;
DC   Protein; auto
TR   HAMAP; MF_03100; -; 1; level=0
XX
Names: Endonuc_su_Slx1
XX
ID   SLX1
case <OC:Vertebrata>
DE   RecName: Full=Structure-specific endonuclease subunit <gene_name>;
DE            EC=3.1.-.-;
DE   AltName: Full=GIY-YIG domain-containing protein 1;
else case <OC:Caenorhabditis>
DE   RecName: Full=Structure-specific endonuclease subunit <gene_name>;
DE            EC=3.1.-.-;
DE   AltName: Full=GIY-YIG domain-containing protein 1;
else case <OC:Fungi>
DE   RecName: Full=Structure-specific endonuclease subunit <gene_name>;
DE            EC=3.1.-.-;
else
DE   RecName: Full=Structure-specific endonuclease subunit SLX1 homolog;
DE            EC=3.1.-.-;
end case
case <OC:Vertebrata>
GN   Name=SLX1; Synonyms=GIYD1;
else case <OC:Caenorhabditis>
GN   Name=slx-1; Synonyms=giyd-1;
else case <OC:Fungi>
GN   Name=SLX1;
end case
XX
case <OC:Mammalia>
CC   -!- FUNCTION: Catalytic subunit of the @gn(SLX1)-@gn(SLX4) structure-
CC       specific endonuclease that resolves DNA secondary structures generated
CC       during DNA repair and recombination. Has endonuclease activity towards
CC       branched DNA substrates, introducing single-strand cuts in duplex DNA
CC       close to junctions with ss-DNA. Has a preference for 5'-flap
CC       structures, and promotes symmetrical cleavage of static and migrating
CC       Holliday junctions (HJs). Resolves HJs by generating two pairs of
CC       ligatable, nicked duplex products.
else case <OC:Vertebrata> and not <OC:Mammalia>
CC   -!- FUNCTION: Catalytic subunit of the @gn(SLX1)-@gn(SLX4) structure-
CC       specific endonuclease that resolves DNA secondary structures generated
CC       during DNA repair and recombination. Has endonuclease activity towards
CC       branched DNA substrates, introducing single-strand cuts in duplex DNA
CC       close to junctions with ss-DNA.
else case <OC:Saccharomyces>
CC   -!- FUNCTION: Catalytic subunit of the SLX1-SLX4 structure-specific
CC       endonuclease that resolves DNA secondary structures generated during
CC       DNA repair and recombination. Has endonuclease activity towards
CC       branched DNA substrates, introducing single-strand cuts in duplex DNA
CC       close to junctions with ss-DNA. Has a preference for simple Y, 5'-flap
CC       and replication fork-like structures. It cleaves the strand bearing the
CC       5'-non-homologous arm at the branch site junction and generates
CC       ligatable, nicked products from the 5'-flap or replication fork
CC       substrates. Plays a critical role in maintaining the integrity of the
CC       ribosomal DNA (rDNA) loci, where it has a role in re-starting stalled
CC       replication forks. Has Holliday junction resolvase activity in vitro.
else case <OC:Fungi> and not <OC:Saccharomyces>
CC   -!- FUNCTION: Catalytic subunit of the @gn(SLX1)-@gn(SLX4) structure-
CC       specific endonuclease that resolves DNA secondary structures generated
CC       during DNA repair and recombination. Has endonuclease activity towards
CC       branched DNA substrates, introducing single-strand cuts in duplex DNA
CC       close to junctions with ss-DNA.
else
CC   -!- FUNCTION: Catalytic subunit of a heterodimeric structure-specific
CC       endonuclease that resolves DNA secondary structures generated during
CC       DNA repair and recombination. Has endonuclease activity towards
CC       branched DNA substrates, introducing single-strand cuts in duplex DNA
CC       close to junctions with ss-DNA.
end case
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
case <OC:Vertebrata> or <OC:Fungi>
CC   -!- SUBUNIT: Forms a heterodimer with @gn(SLX4).
else case <OC:Drosophilidae>
CC   -!- SUBUNIT: Forms a heterodimer with mus312/SLX4.
else case <OC:Caenorhabditis>
CC   -!- SUBUNIT: Forms a heterodimer with him-18/slx-4.
else
CC   -!- SUBUNIT: Forms a heterodimer with a member of the SLX4 family.
end case
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the SLX1 family.
XX
DR   PROSITE; PS50164; GIY_YIG; 1; trigger=yes
DR   PROSITE; PS01359; ZF_PHD_1; 0-1; trigger=no
DR   PROSITE; PS50016; ZF_PHD_2; 0-1; trigger=no
DR   Pfam; PF01541; GIY-YIG; 0-1; trigger=no
XX
KW   DNA damage
KW   DNA recombination
KW   DNA repair
KW   Endonuclease
KW   Hydrolase
KW   Nuclease
KW   Nucleus
case <FT:1>
KW   Metal-binding
KW   Zinc
KW   Zinc-finger
end case
XX
GO   GO:0005634; C:nucleus
GO   GO:0033557; C:Slx1-Slx4 complex
case <OC:Mammalia>
GO   GO:0008821; F:crossover junction DNA endonuclease activity
end case
case <OC:Mammalia> or <OC:Saccharomyces>
GO   GO:0017108; F:5'-flap endonuclease activity
else
GO   GO:0004520; F:DNA endonuclease activity
end case
GO   GO:0006310; P:DNA recombination
GO   GO:0006281; P:DNA repair
XX
FT   From: SLX1_HUMAN (Q9BQ83)
FT   ZN_FING         186..238
FT                   /note="SLX1-type"
FT   Condition: C-x(1,2)-C-x*-C-x(1,7)-C-x(1,4)-[CH]-x(2)-C-x*-C-x(2)-C
XX
Size: 246-705;
Related: None;
Template: P38324; Q9BQ83; Q9P7M3;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: in TRYCR
Plasmid: None
Comments: None
XX
# Revision 1.10 2023/02/07
//