AC   MF_03102;
DC   Protein; auto
TR   HAMAP; MF_03102; -; 1; level=0
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Names: Mdm10
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ID   MDM10
DE   RecName: Full=Mitochondrial distribution and morphology protein 10;
DE   AltName: Full=Mitochondrial inheritance component <gene_name>;
GN   Name=MDM10;
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CC   -!- FUNCTION: Component of the ERMES/MDM complex, which serves as a
CC       molecular tether to connect the endoplasmic reticulum and mitochondria.
CC       Components of this complex are involved in the control of mitochondrial
CC       shape and protein biogenesis and may function in phospholipid exchange.
CC       <gene_name> is involved in the late assembly steps of the general
CC       translocase of the mitochondrial outer membrane (TOM complex).
CC       Functions in the @gn(TOM40)-specific route of the assembly of outer
CC       membrane beta-barrel proteins, including the association of @gn(TOM40)
CC       with the receptor @gn(TOM22) and small TOM proteins. Can associate with
CC       the SAM(core) complex as well as the @gn(MDM12)-@gn(MMM1) complex, both
CC       involved in late steps of the major beta-barrel assembly pathway, that
CC       is responsible for biogenesis of all outer membrane beta-barrel
CC       proteins. May act as a switch that shuttles between both complexes and
CC       channels precursor proteins into the @gn(TOM40)-specific pathway. Plays
CC       a role in mitochondrial morphology and in the inheritance of
CC       mitochondria.
case <OC:Saccharomyces>
CC   -!- SUBUNIT: Component of the ER-mitochondria encounter structure (ERMES)
CC       or MDM complex, composed of MMM1, <gene_name>, MDM12 and MDM34.
CC       Associates with the mitochondrial outer membrane sorting assembly
CC       machinery SAM(core) complex, which consists of SAM35, SAM37 and SAM50,
CC       to form a SAM(holo) complex.
else
CC   -!- SUBUNIT: Component of the ER-mitochondria encounter structure (ERMES)
CC       or MDM complex, composed of @gn(MMM1), <gene_name>, @gn(MDM12) and
CC       @gn(MDM34). Associates with the mitochondrial outer membrane sorting
CC       assembly machinery SAM(core) complex.
end case
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane; Multi-pass membrane
CC       protein. Note=The ERMES/MDM complex localizes to a few discrete foci
CC       (around 10 per single cell), that represent mitochondria-endoplasmic
CC       reticulum junctions. These foci are often found next to mtDNA
CC       nucleoids.
CC   -!- DOMAIN: Lacks alpha-helical transmembrane segments, suggesting that it
CC       resides in the membrane via beta-sheet conformations similar to those
CC       predicted for other outer membrane proteins and porin.
CC   -!- SIMILARITY: Belongs to the MDM10 family.
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KW   Membrane
KW   Mitochondrion
KW   Mitochondrion outer membrane
KW   Transmembrane
KW   Transmembrane beta strand
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GO   GO:0005741; C:mitochondrial outer membrane
GO   GO:0032865; C:ERMES complex
GO   GO:0000002; P:mitochondrial genome maintenance
GO   GO:0070096; P:mitochondrial outer membrane translocase complex assembly
GO   GO:1990456; P:mitochondrion-endoplasmic reticulum membrane tethering
GO   GO:0045040; P:protein insertion into mitochondrial outer membrane
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Size: 184-646;
Related: None;
Template: P18409;
Scope:
 Eukaryota; Fungi
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.9 2022/09/29
//