AC   MF_03103;
DC   Protein; auto
TR   HAMAP; MF_03103; -; 1; level=0
XX
Names: Mmm1
XX
ID   MMM1
case <OC:Saccharomyces>
DE   RecName: Full=Maintenance of mitochondrial morphology protein 1;
DE   AltName: Full=Mitochondrial outer membrane protein <gene_name>;
DE   AltName: Full=Yeast mitochondrial escape protein 6;
else
DE   RecName: Full=Maintenance of mitochondrial morphology protein 1;
end case
GN   Name=MMM1;
XX
CC   -!- FUNCTION: Component of the ERMES/MDM complex, which serves as a
CC       molecular tether to connect the endoplasmic reticulum (ER) and
CC       mitochondria. Components of this complex are involved in the control of
CC       mitochondrial shape and protein biogenesis, and function in
CC       nonvesicular lipid trafficking between the ER and mitochondria. The
CC       @gn(MDM12)-<gene_name> subcomplex functions in the major beta-barrel
CC       assembly pathway that is responsible for biogenesis of all outer
CC       membrane beta-barrel proteins, and acts in a late step after the SAM
CC       complex. The @gn(MDM10)-@gn(MDM12)-<gene_name> subcomplex further acts
CC       in the TOM40-specific pathway after the action of the
CC       @gn(MDM12)-<gene_name> complex. Essential for establishing and
CC       maintaining the structure of mitochondria and maintenance of mtDNA
CC       nucleoids.
CC   -!- SUBUNIT: Homodimer. Component of the ER-mitochondria encounter
CC       structure (ERMES) or MDM complex, composed of <gene_name>, @gn(MDM10),
CC       @gn(MDM12) and @gn(MDM34). A <gene_name> homodimer associates with one
CC       molecule of @gn(MDM12) on each side in a pairwise head-to-tail manner,
CC       and the SMP-LTD domains of <gene_name> and @gn(MDM12) generate a
CC       continuous hydrophobic tunnel for phospholipid trafficking.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type
CC       I membrane protein. Note=The ERMES/MDM complex localizes to a few
CC       discrete foci (around 10 per single cell), that represent mitochondria-
CC       endoplasmic reticulum junctions. These foci are often found next to
CC       mtDNA nucleoids.
CC   -!- SIMILARITY: Belongs to the MMM1 family.
XX
DR   PROSITE; PS51847; SMP; 1; trigger=yes
DR   Pfam; PF10296; DUF2404; 1; trigger=no
DR   General; Transmembrane; -; 0-1; trigger=no
XX
KW   Endoplasmic reticulum
KW   Membrane
KW   Transmembrane
KW   Transmembrane helix
XX
GO   GO:0005789; C:endoplasmic reticulum membrane
GO   GO:0032865; C:ERMES complex
GO   GO:0000002; P:mitochondrial genome maintenance
GO   GO:0045040; P:protein insertion into mitochondrial outer membrane
XX
FT   From: MMM1_YEAST (P41800)
FT   TOPO_DOM        Nter..100
FT                   /note="Lumenal"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT   TOPO_DOM        122..Cter
FT                   /note="Cytoplasmic"
XX
Size: 291-591;
Related: None;
Template: P41800;
Scope:
 Eukaryota; Fungi
Fusion:
 Nter: None
 Cter: None
Duplicate: in YARLI
Plasmid: None
Comments: None
XX
# Revision 1.11 2022/09/29
//