AC MF_03104; DC Protein; auto TR HAMAP; MF_03104; -; 1; level=0 XX Names: Mdm12 XX ID MDM12 DE RecName: Full=Mitochondrial distribution and morphology protein 12; DE AltName: Full=Mitochondrial inheritance component ; GN Name=MDM12; XX CC -!- FUNCTION: Component of the ERMES/MDM complex, which serves as a CC molecular tether to connect the endoplasmic reticulum (ER) and CC mitochondria. Components of this complex are involved in the control of CC mitochondrial shape and protein biogenesis, and function in CC nonvesicular lipid trafficking between the ER and mitochondria. CC is required for the interaction of the ER-resident membrane CC protein @gn(MMM1) and the outer mitochondrial membrane-resident beta- CC barrel protein @gn(MDM10). The -@gn(MMM1) subcomplex CC functions in the major beta-barrel assembly pathway that is responsible CC for biogenesis of all mitochondrial outer membrane beta-barrel CC proteins, and acts in a late step after the SAM complex. The CC @gn(MDM10)--@gn(MMM1) subcomplex further acts in the CC @gn(TOM40)-specific pathway after the action of the CC -@gn(MMM1) complex. Essential for establishing and CC maintaining the structure of mitochondria and maintenance of mtDNA CC nucleoids. case CC -!- SUBUNIT: Component of the ER-mitochondria encounter structure (ERMES) CC or MDM complex, composed of @gn(MMM1), @gn(MDM10), and CC @gn(MDM34). A @gn(MMM1) homodimer associates with one molecule of CC on each side in a pairwise head-to-tail manner, and the CC SMP-LTD domains of @gn(MMM1) and generate a continuous CC hydrophobic tunnel for phospholipid trafficking. Interacts with PUF3. else CC -!- SUBUNIT: Component of the ER-mitochondria encounter structure (ERMES) CC or MDM complex, composed of @gn(MMM1), @gn(MDM10), and CC @gn(MDM34). A @gn(MMM1) homodimer associates with one molecule of CC on each side in a pairwise head-to-tail manner, and the CC SMP-LTD domains of @gn(MMM1) and generate a continuous CC hydrophobic tunnel for phospholipid trafficking. end case CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane; Peripheral membrane CC protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral CC membrane protein; Cytoplasmic side. Note=The ERMES/MDM complex CC localizes to a few discrete foci (around 10 per single cell), that CC represent mitochondria-endoplasmic reticulum junctions. These foci are CC often found next to mtDNA nucleoids. CC -!- SIMILARITY: Belongs to the MDM12 family. XX DR PROSITE; PS51847; SMP; 1; trigger=yes XX KW Endoplasmic reticulum KW Membrane KW Mitochondrion KW Mitochondrion outer membrane XX GO GO:0005789; C:endoplasmic reticulum membrane GO GO:0005741; C:mitochondrial outer membrane GO GO:0032865; C:ERMES complex GO GO:0000002; P:mitochondrial genome maintenance GO GO:0045040; P:protein insertion into mitochondrial outer membrane XX Size: 239-675; Related: None; Template: Q92328; Scope: Eukaryota; Fungi Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.8 2019/11/20 //