AC MF_03105; DC Protein; auto TR HAMAP; MF_03105; -; 1; level=0 XX Names: Mdm34 XX ID MDM34 case DE RecName: Full=Mitochondrial distribution and morphology protein 34; DE AltName: Full=Mitochondrial outer membrane protein MMM2; else DE RecName: Full=Mitochondrial distribution and morphology protein 34; end case case GN Name=MDM34; Synonyms=MMM2; else GN Name=MDM34; end case XX CC -!- FUNCTION: Component of the ERMES/MDM complex, which serves as a CC molecular tether to connect the endoplasmic reticulum (ER) and CC mitochondria. Components of this complex are involved in the control of CC mitochondrial shape and protein biogenesis, and function in CC nonvesicular lipid trafficking between the ER and mitochondria. CC is required for the interaction of the ER-resident membrane CC protein @gn(MMM1) and the outer mitochondrial membrane-resident beta- CC barrel protein @gn(MDM10). CC -!- SUBUNIT: Component of the ER-mitochondria encounter structure (ERMES) CC or MDM complex, composed of @gn(MMM1), @gn(MDM10), @gn(MDM12) and CC . CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane; Multi-pass membrane CC protein. Note=The ERMES/MDM complex localizes to a few discrete foci CC (around 10 per single cell), that represent mitochondria-endoplasmic CC reticulum junctions. These foci are often found next to mtDNA CC nucleoids. CC -!- DOMAIN: Lacks alpha-helical transmembrane segments, suggesting that it CC resides in the membrane via beta-sheet conformations similar to those CC predicted for other outer membrane proteins and porin. case CC -!- PTM: Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin- CC protein ligase complex containing the F-box protein MDM30. CC Ubiquitination is important for mitochondrial integrity. end case CC -!- SIMILARITY: Belongs to the MDM34 family. XX DR PROSITE; PS51847; SMP; 1; trigger=yes XX KW Membrane KW Mitochondrion KW Mitochondrion outer membrane KW Transmembrane KW Transmembrane beta strand case KW Ubl conjugation end case XX GO GO:0005741; C:mitochondrial outer membrane GO GO:0032865; C:ERMES complex GO GO:0000002; P:mitochondrial genome maintenance XX FT None XX Size: 343-1097; Related: None; Template: P53083; Scope: Eukaryota; Fungi Fusion: Nter: None Cter: None Duplicate: in PENCW Plasmid: None Comments: None XX # Revision 1.8 2022/09/29 //