AC   MF_03107;
DC   Protein; auto
TR   HAMAP; MF_03107; -; 1; level=0
XX
Names: 3_ketoreductase
XX
ID   MKAR
DE   RecName: Full=Very-long-chain 3-oxoacyl-CoA reductase;
DE            EC=1.1.1.330;
DE   AltName: Full=3-ketoacyl-CoA reductase;
DE            Short=3-ketoreductase;
DE            Short=KAR;
DE   AltName: Full=Microsomal beta-keto-reductase;
XX
CC   -!- FUNCTION: Component of the microsomal membrane bound fatty acid
CC       elongation system, which produces the 26-carbon very long-chain fatty
CC       acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-
CC       ketoacyl-CoA intermediate that is formed in each cycle of fatty acid
CC       elongation. VLCFAs serve as precursors for ceramide and sphingolipids.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-
CC         long-chain 3-oxoacyl-CoA + H(+) + NADPH; Xref=Rhea:RHEA:48680,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:85440, ChEBI:CHEBI:90725; EC=1.1.1.330;
case <OC:Saccharomyces>
CC   -!- SUBUNIT: Interacts with the fatty acid elongation system components
CC       ELO3 and TSC13.
end case
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass
CC       membrane protein.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family.
XX
DR   PROSITE; PS00061; ADH_SHORT; 1; trigger=no
DR   Pfam; PF00106; adh_short; 1; trigger=no
DR   PRINTS; PR00081; GDHRDH; 1; trigger=no
DR   PRINTS; PR00080; SDRFAMILY; 1; trigger=no
XX
KW   Endoplasmic reticulum
KW   Fatty acid biosynthesis
KW   Fatty acid metabolism
KW   Lipid biosynthesis
KW   Lipid metabolism
KW   Membrane
KW   NADP
KW   Oxidoreductase
KW   Transmembrane
KW   Transmembrane helix
XX
GO   GO:0005789; C:endoplasmic reticulum membrane
GO   GO:0045703; F:ketoreductase activity
GO   GO:0030497; P:fatty acid elongation
XX
FT   From: MKAR_YEAST (P38286)
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT   ACT_SITE        223
FT                   /note="Proton acceptor"
FT   Condition: Y
FT   BINDING         210
FT                   /ligand="substrate"
FT   Condition: S
XX
Size: 324-395;
Related: None;
Template: P38286;
Scope:
 Eukaryota; Fungi
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.9 2022/05/14
//