AC   MF_03113;
DC   Protein; auto
TR   HAMAP; MF_03113; -; 1; level=0
XX
Names: Get1
XX
ID   GET1
case <OC:Saccharomycotina>
DE   RecName: Full=Golgi to ER traffic protein 1;
DE   AltName: Full=Guided entry of tail-anchored proteins 1;
else
DE   RecName: Full=Protein <gene_name>;
DE   AltName: Full=Guided entry of tail-anchored proteins 1;
end case
GN   Name=GET1;
XX
case <OC:Saccharomycotina>
CC   -!- FUNCTION: Required for the post-translational delivery of tail-anchored
CC       (TA) proteins to the endoplasmic reticulum. Together with @gn(GET2),
CC       acts as a membrane receptor for soluble @gn(GET3), which recognizes and
CC       selectively binds the transmembrane domain of TA proteins in the
CC       cytosol. The GET complex cooperates with the HDEL receptor @gn(ERD2) to
CC       mediate the ATP-dependent retrieval of resident ER proteins that
CC       contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
CC   -!- SUBUNIT: Component of the Golgi to ER traffic (GET) complex, which is
CC       composed of @gn(GET1), @gn(GET2) and @gn(GET3). Within the complex,
CC       @gn(GET1) and @gn(GET2) form a heterotetramer which is stabilized by
CC       phosphatidylinositol binding and which binds to the @gn(GET3)
CC       homodimer.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC       membrane protein. Golgi apparatus membrane; Multi-pass membrane
CC       protein.
else
CC   -!- FUNCTION: Required for the post-translational delivery of tail-anchored
CC       (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor
CC       for soluble @gn(GET3), which recognizes and selectively binds the
CC       transmembrane domain of TA proteins in the cytosol.
CC   -!- SUBUNIT: Interacts with @gn(GET3).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC       membrane protein.
end case
CC   -!- SIMILARITY: Belongs to the WRB/GET1 family.
XX
DR   Pfam; PF04420; CHD5; 1; trigger=no
DR   General; Coiled_coil; -; 0-unlimited; trigger=yes
XX
KW   Endoplasmic reticulum
KW   Membrane
KW   Transmembrane
KW   Transmembrane helix
KW   Transport
case <OC:Saccharomycotina>
KW   ER-Golgi transport
KW   Golgi apparatus
end case
XX
case <OC:Saccharomycotina>
GO   GO:0043529; C:GET complex
else
GO   GO:0005783; C:endoplasmic reticulum
end case
GO   GO:0045048; P:protein insertion into ER membrane
XX
FT   From: GET1_YEAST (P53192)
FT   TOPO_DOM        Nter..1
FT                   /note="Lumenal"
FT   TRANSMEM        2..21
FT                   /note="Helical"
FT   TOPO_DOM        22..104
FT                   /note="Cytoplasmic"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT   TOPO_DOM        126..181
FT                   /note="Lumenal"
FT   TRANSMEM        182..198
FT                   /note="Helical"
FT   TOPO_DOM        199..Cter
FT                   /note="Cytoplasmic"
XX
Size: 170-237;
Related: None;
Template: P53192;
Scope:
 Eukaryota; Fungi
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.5 2021/02/26
//