AC   MF_03114;
DC   Protein; auto
TR   HAMAP; MF_03114; -; 1; level=0
XX
Names: Get2
XX
ID   GET2
case <OC:Saccharomyces>
DE   RecName: Full=Golgi to ER traffic protein 2;
DE   AltName: Full=Hydroxyurea resistance protein 2;
DE   AltName: Full=Required for meiotic nuclear division protein 7;
else
DE   RecName: Full=Golgi to ER traffic protein 2;
end case
case <OC:Saccharomyces>
GN   Name=GET2; Synonyms=HUR2, RMD7;
else
GN   Name=GET2;
end case
XX
case <OC:Saccharomyces>
CC   -!- FUNCTION: Required for the post-translational delivery of tail-anchored
CC       (TA) proteins to the endoplasmic reticulum. Together with @gn(GET1),
CC       acts as a membrane receptor for soluble @gn(GET3), which recognizes and
CC       selectively binds the transmembrane domain of TA proteins in the
CC       cytosol. The GET complex cooperates with the HDEL receptor @gn(ERD2) to
CC       mediate the ATP-dependent retrieval of resident ER proteins that
CC       contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
CC       Involved in DNA replication and DNA damage response and also in cell
CC       wall function.
else
CC   -!- FUNCTION: Required for the post-translational delivery of tail-anchored
CC       (TA) proteins to the endoplasmic reticulum. Together with @gn(GET1),
CC       acts as a membrane receptor for soluble @gn(GET3), which recognizes and
CC       selectively binds the transmembrane domain of TA proteins in the
CC       cytosol. The GET complex cooperates with the HDEL receptor @gn(ERD2) to
CC       mediate the ATP-dependent retrieval of resident ER proteins that
CC       contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
end case
CC   -!- SUBUNIT: Component of the Golgi to ER traffic (GET) complex, which is
CC       composed of @gn(GET1), @gn(GET2) and @gn(GET3). Within the complex,
CC       @gn(GET1) and @gn(GET2) form a heterotetramer which is stabilized by
CC       phosphatidylinositol binding and which binds to the @gn(GET3)
CC       homodimer.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC       membrane protein. Golgi apparatus membrane; Multi-pass membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the GET2 family.
XX
DR   Pfam; PF08690; GET2; 1; trigger=no
XX
KW   Endoplasmic reticulum
KW   ER-Golgi transport
KW   Golgi apparatus
KW   Membrane
KW   Transmembrane
KW   Transmembrane helix
KW   Transport
case <FTTag:glyco>
KW   Glycoprotein
end case
XX
GO   GO:0043529; C:GET complex
GO   GO:0045048; P:protein insertion into ER membrane
XX
FT   From: GET2_YEAST (P40056)
FT   TOPO_DOM        Nter..148
FT                   /note="Cytoplasmic"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT   TOPO_DOM        170..196
FT                   /note="Lumenal"
FT   TRANSMEM        197..216
FT                   /note="Helical"
FT   TOPO_DOM        217..263
FT                   /note="Cytoplasmic"
FT   TRANSMEM        264..284
FT                   /note="Helical"
FT   TOPO_DOM        285..Cter
FT                   /note="Lumenal"
case <OC:Saccharomyces>
FT   CARBOHYD        173
FT                   /note="N-linked (GlcNAc...) asparagine"
FT   Tag: glyco; Condition: N
FT   CARBOHYD        196
FT                   /note="N-linked (GlcNAc...) asparagine"
FT   Tag: glyco; Condition: N
end case
XX
Size: 266-357;
Related: None;
Template: P40056;
Scope:
 Eukaryota; Saccharomycotina
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.6 2021/02/26
//