AC   MF_03116;
DC   Protein; auto
TR   HAMAP; MF_03116; -; 1; level=0
XX
Names: Salvage_MtnB_euk
XX
ID   MTNB
case <OC:Mammalia>
DE   RecName: Full=Methylthioribulose-1-phosphate dehydratase;
DE            Short=MTRu-1-P dehydratase;
DE            EC=4.2.1.109;
DE   AltName: Full=APAF1-interacting protein;
else case <OC:Vertebrata>
DE   RecName: Full=Methylthioribulose-1-phosphate dehydratase;
DE            Short=MTRu-1-P dehydratase;
DE            EC=4.2.1.109;
DE   AltName: Full=APAF1-interacting protein homolog;
else case <OC:Fungi>
DE   RecName: Full=Methylthioribulose-1-phosphate dehydratase;
DE            Short=MTRu-1-P dehydratase;
DE            EC=4.2.1.109;
else
DE   RecName: Full=Probable methylthioribulose-1-phosphate dehydratase;
DE            Short=MTRu-1-P dehydratase;
DE            EC=4.2.1.109;
end case
case <OC:Vertebrata>
GN   Name=APIP;
else case <OC:Fungi>
GN   Name=MDE1;
end case
XX
case <OC:Mammalia>
CC   -!- FUNCTION: Catalyzes the dehydration of methylthioribulose-1-phosphate
CC       (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
CC       Functions in the methionine salvage pathway, which plays a key role in
CC       cancer, apoptosis, microbial proliferation and inflammation. May
CC       inhibit the CASP1-related inflammatory response (pyroptosis), the
CC       CASP9-dependent apoptotic pathway and the cytochrome c-dependent and
CC       APAF1-mediated cell death.
else case <OC:Vertebrata>
CC   -!- FUNCTION: Catalyzes the dehydration of methylthioribulose-1-phosphate
CC       (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
CC       Functions in the methionine salvage pathway. May play a role in
CC       apoptosis.
else
CC   -!- FUNCTION: Catalyzes the dehydration of methylthioribulose-1-phosphate
CC       (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-methyl-5-thio-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-
CC         dioxopentyl phosphate + H2O; Xref=Rhea:RHEA:15549, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:58548, ChEBI:CHEBI:58828; EC=4.2.1.109;
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 1 zinc ion per subunit.;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via salvage
CC       pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate:
CC       step 2/6.
case <OC:Mammalia>
CC   -!- SUBUNIT: Homotetramer. Interacts with APAF1. May interact with CASP1.
end case
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the aldolase class II family. MtnB subfamily.
XX
DR   Pfam; PF00596; Aldolase_II; 1; trigger=no
DR   NCBIfam; TIGR03328; salvage_mtnB; 1; trigger=no
XX
KW   Amino-acid biosynthesis
KW   Cytoplasm
KW   Lyase
KW   Metal-binding
KW   Methionine biosynthesis
KW   Zinc
case <OC:Vertebrata>
KW   Apoptosis
end case
XX
GO   GO:0008270; F:zinc ion binding
GO   GO:0046570; F:methylthioribulose 1-phosphate dehydratase activity
GO   GO:0019284; P:L-methionine salvage from S-adenosylmethionine
XX
FT   From: MTNB_HUMAN (Q96GX9)
FT   ACT_SITE        139
FT                   /note="Proton donor/acceptor"
FT   Condition: E
FT   BINDING         115
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Condition: H
FT   BINDING         117
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Condition: H
FT   BINDING         195
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Condition: H
FT   BINDING         97
FT                   /ligand="substrate"
FT   Condition: C
XX
Size: 169-279;
Related: MF_03118!;
Template: Q96GX9; P47095;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.15 2023/06/01
//