AC   MF_03119;
DC   Protein; auto
c?   <OC:Eukaryota>
TR   HAMAP; MF_01678; -; 1; level=0
XX
Names: Salvage_MtnA_euk
XX
ID   MTNA
DE   RecName: Full=Methylthioribose-1-phosphate isomerase;
DE            Short=M1Pi;
DE            Short=MTR-1-P isomerase;
DE            EC=5.3.1.23;
DE   AltName: Full=S-methyl-5-thioribose-1-phosphate isomerase;
DE   AltName: Full=Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein;
case <OC:Vertebrata> or <OC:Fungi>
GN   Name=MRI1;
end case
XX
CC   -!- FUNCTION: Catalyzes the interconversion of methylthioribose-1-phosphate
CC       (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-
CC         D-ribulose 1-phosphate; Xref=Rhea:RHEA:19989, ChEBI:CHEBI:58533,
CC         ChEBI:CHEBI:58548; EC=5.3.1.23;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via salvage
CC       pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate:
CC       step 1/6.
case <OC:Saccharomyces>
CC   -!- SUBUNIT: Homodimer.
end case
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
CC   -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family.
CC       MtnA subfamily.
XX
DR   Pfam; PF01008; IF-2B; 1; trigger=no
DR   NCBIfam; TIGR00524; EIF-2B_rel; 1; trigger=no
DR   NCBIfam; TIGR00512; Salvage_mtnA; 1; trigger=no
XX
KW   Amino-acid biosynthesis
KW   Isomerase
KW   Methionine biosynthesis
KW   Cytoplasm
KW   Nucleus
XX
GO   GO:0046523; F:S-methyl-5-thioribose-1-phosphate isomerase activity
GO   GO:0019284; P:L-methionine salvage from S-adenosylmethionine
GO   GO:0005737; C:cytoplasm
GO   GO:0005634; C:nucleus
XX
FT   From: MTNA_HUMAN (Q9BV20)
FT   ACT_SITE        248
FT                   /note="Proton donor"
FT   Condition: D
FT   SITE            168
FT                   /note="Transition state stabilizer"
FT   Condition: C
XX
Size: 350-445;
Related: None;
Template: Q9BV20; Q06489;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: in TRYCR
Plasmid: None
Comments: None
XX
# Revision 1.8 2023/06/01
//