AC   MF_03121;
DC   Protein; auto
TR   HAMAP; MF_03121; -; 1; level=0
XX
Names: lonp2_euk
XX
ID   LONP2
case <OC:Mammalia>
DE   RecName: Full=Lon protease homolog 2, peroxisomal;
DE            EC=3.4.21.-;
DE   AltName: Full=Lon protease-like protein 2;
DE            Short=Lon protease 2;
DE   AltName: Full=Peroxisomal Lon protease;
else
DE   RecName: Full=Lon protease homolog 2, peroxisomal;
DE            EC=3.4.21.-;
end case
case <OC:Vertebrata>
GN   Name=LONP2;
end case
XX
case <OC:Mammalia>
CC   -!- FUNCTION: ATP-dependent serine protease that mediates the selective
CC       degradation of misfolded and unassembled polypeptides in the
CC       peroxisomal matrix. Necessary for type 2 peroxisome targeting signal
CC       (PTS2)-containing protein processing and facilitates peroxisome matrix
CC       protein import. May indirectly regulate peroxisomal fatty acid beta-
CC       oxidation through degradation of the self-processed forms of TYSND1.
CC   -!- SUBUNIT: Interacts with PEX5. Interacts with TYSND1.
else
CC   -!- FUNCTION: ATP-dependent serine protease that mediates the selective
CC       degradation of misfolded and unassembled polypeptides in the
CC       peroxisomal matrix. Necessary for type 2 peroxisome targeting signal
CC       (PTS2)-containing protein processing and facilitates peroxisome matrix
CC       protein import.
end case
CC   -!- SUBCELLULAR LOCATION: Peroxisome matrix.
CC   -!- SIMILARITY: Belongs to the peptidase S16 family.
XX
DR   PROSITE; PS51787; LON_N; 1; trigger=yes
DR   PROSITE; PS51786; LON_PROTEOLYTIC; 1; trigger=yes
DR   PROSITE; PS01046; LON_SER; 1; trigger=no
DR   Pfam; PF00004; AAA; 1; trigger=no
DR   Pfam; PF02190; LON; 1; trigger=no
DR   PRINTS; PR00830; ENDOLAPTASE; 1; trigger=no
DR   NCBIfam; TIGR00763; lon; 1; trigger=no
XX
case <FTTag:ATP>
KW   ATP-binding
KW   Nucleotide-binding
end case
KW   Hydrolase
KW   Peroxisome
KW   Protease
KW   Serine protease
XX
GO   GO:0005782; C:peroxisomal matrix
GO   GO:0005524; F:ATP binding
GO   GO:0016887; F:ATP hydrolysis activity
GO   GO:0004176; F:ATP-dependent peptidase activity
GO   GO:0004252; F:serine-type endopeptidase activity
GO   GO:0006515; P:protein quality control for misfolded or incompletely synthesized proteins
GO   GO:0016485; P:protein processing
GO   GO:0016558; P:protein import into peroxisome matrix
XX
FT   From: LONP2_HUMAN (Q86WA8)
FT   BINDING         375..382
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Tag: ATP; Condition: G-P-[PT]-G-[ITV]-G-K-T
FT   ACT_SITE        743
FT   Condition: S
FT   ACT_SITE        786
FT   Condition: K
FT   MOTIF           Cter-2..Cter
FT                   /note="Microbody targeting signal"
XX
Size: 773-1258;
Related: MF_03120; MF_01973;
Template: Q86WA8; O64948; Q2V573;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.12 2023/06/01
//