AC   MF_03132;
DC   Protein; auto
c?   <OC:Eukaryota>
TR   HAMAP; MF_00032; -; 1; level=0
XX
Names: eIF-6_euk
XX
ID   IF6
DE   RecName: Full=Eukaryotic translation initiation factor 6;
DE            Short=eIF-6;
case <OC:Fungi>
GN   Name=TIF6;
else case <OC:Mammalia>
GN   Name=EIF6; Synonyms=ITGB4BP;
else case <OC:Caenorhabditis>
GN   Name=eif-6;
else case <OC:Drosophilidae>
GN   Name=eIF6;
else
GN   Name=EIF6;
end case
XX
case <OC:Mammalia>
CC   -!- FUNCTION: Binds to the 60S ribosomal subunit and prevents its
CC       association with the 40S ribosomal subunit to form the 80S initiation
CC       complex in the cytoplasm. Behaves as a stimulatory translation
CC       initiation factor downstream insulin/growth factors. Is also involved
CC       in ribosome biogenesis. Associates with pre-60S subunits in the nucleus
CC       and is involved in its nuclear export. Cytoplasmic release of TIF6 from
CC       60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-
CC       dependent protein kinase C activity. In tissues responsive to insulin,
CC       controls fatty acid synthesis and glycolysis by exerting translational
CC       control of adipogenic transcription factors such as CEBPB, CEBPD and
CC       ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-
CC       dependent megakaryocyte maturation and platelets formation, controls
CC       the expression of mitochondrial respiratory chain genes involved in
CC       reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated
CC       gene silencing by the RNA-induced silencing complex (RISC). Required
CC       for both miRNA-mediated translational repression and miRNA-mediated
CC       cleavage of complementary mRNAs by RISC. Modulates cell cycle
CC       progression and global translation of pre-B cells, its activation seems
CC       to be rate-limiting in tumorigenesis and tumor growth.
else case <OC:Caenorhabditis>
CC   -!- FUNCTION: Binds to the 60S ribosomal subunit and prevents its
CC       association with the 40S ribosomal subunit to form the 80S initiation
CC       complex in the cytoplasm. May also be involved in ribosome biogenesis.
CC       Involved in miRNA-mediated gene silencing.
else case <OC:Saccharomyces>
CC   -!- FUNCTION: Binds to the 60S ribosomal subunit and prevents its
CC       association with the 40S ribosomal subunit to form the 80S initiation
CC       complex in the cytoplasm. Is also involved in ribosome biogenesis.
CC       Associates with pre-60S subunits in the nucleus and is involved in its
CC       nuclear export. Cytoplasmic release of TIF6 from 60S subunits and
CC       nuclear relocalization is promoted by the GTPase RIA1/EFL1 and by SDO1.
CC       Also required for pre-rRNA processing.
else case <OC:Fungi> and not <OC:Saccharomyces>
CC   -!- FUNCTION: Binds to the 60S ribosomal subunit and prevents its
CC       association with the 40S ribosomal subunit to form the 80S initiation
CC       complex in the cytoplasm. Is also involved in ribosome biogenesis.
CC       Associates with pre-60S subunits in the nucleus and is involved in its
CC       nuclear export.
else
CC   -!- FUNCTION: Binds to the 60S ribosomal subunit and prevents its
CC       association with the 40S ribosomal subunit to form the 80S initiation
CC       complex in the cytoplasm. May also be involved in ribosome biogenesis.
end case
case <OC:Mammalia>
CC   -!- SUBUNIT: Monomer. Associates with the 60S ribosomal subunit. Interacts
CC       with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they
CC       form a large RNA-induced silencing complex (RISC).
else
CC   -!- SUBUNIT: Monomer. Associates with the 60S ribosomal subunit.
end case
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleolus. Note=Shuttles
CC       between cytoplasm and nucleus/nucleolus.
case (<OC:Mammalia> or <OC:Fungi>) and <FTGroup:1>
CC   -!- PTM: Phosphorylation at #{Ser-174} and #{Ser-175} promotes nuclear
CC       export.
end case
CC   -!- SIMILARITY: Belongs to the eIF-6 family.
XX
DR   Pfam; PF01912; eIF-6; 1; trigger=no
DR   NCBIfam; TIGR00323; EIF-6; 1; trigger=no
DR   PIRSF; PIRSF006413; IF-6; 1; trigger=no
XX
KW   Cytoplasm
KW   Initiation factor
KW   Nucleus
KW   Protein biosynthesis
KW   Ribosome biogenesis
case (<OC:Mammalia> or <OC:Fungi>) and <FTGroup:1> or <FTTag:phospho>
KW   Phosphoprotein
end case
XX
GO   GO:0005737; C:cytoplasm
GO   GO:0005730; C:nucleolus
GO   GO:0043023; F:ribosomal large subunit binding
GO   GO:0003743; F:translation initiation factor activity
GO   GO:0042256; P:cytosolic ribosome assembly
GO   GO:0042273; P:ribosomal large subunit biogenesis
GO   GO:0006413; P:translational initiation
case <OC:Mammalia> or <OC:Fungi>
GO   GO:0000054; P:ribosomal subunit export from nucleus
end case
XX
FT   From: IF6_YEAST (Q12522)
case <OC:Mammalia> or <OC:Fungi>
FT   MOD_RES         174
FT                   /note="Phosphoserine; by CK1"
FT   Optional; Group: 1; Condition: S
FT   MOD_RES         175
FT                   /note="Phosphoserine; by CK1"
FT   Optional; Group: 1; Condition: S
end case
FT   From: IF6_HUMAN (P56537)
case <OC:Mammalia>
FT   MOD_RES         165
FT                   /note="Phosphothreonine"
FT   Tag: phospho; Condition: T
FT   MOD_RES         166
FT                   /note="Phosphoserine"
FT   Tag: phospho; Condition: S
end case
XX
Size: 226-284;
Related: None;
Template: P56537; Q12522; O55135;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: in ARATH, GIALA, MAIZE, ORYSJ, PARTE, PHYPA, PICSI, POPTR, SORBI,
 TRIVA
Plasmid: None
Comments: None
XX
# Revision 1.7 2023/06/01
//