AC   MF_03141;
DC   Protein; auto
TR   HAMAP; MF_03141; -; 1; level=0
XX
Names: lis1
XX
ID   LIS1
case <OC:Mammalia>
DE   RecName: Full=Platelet-activating factor acetylhydrolase IB subunit alpha;
DE   AltName: Full=Lissencephaly-1 protein;
DE            Short=LIS-1;
DE   AltName: Full=PAF acetylhydrolase 45 kDa subunit;
DE            Short=PAF-AH 45 kDa subunit;
DE   AltName: Full=PAF-AH alpha;
DE            Short=PAFAH alpha;
else case <OC:Eurotiales>
DE   RecName: Full=Nuclear distribution protein nudF;
DE   AltName: Full=Lissencephaly-1 homolog;
DE            Short=LIS-1;
else case <OC:Fungi> and not <OC:Eurotiales>
DE   RecName: Full=Nuclear distribution protein PAC1;
DE   AltName: Full=Lissencephaly-1 homolog;
DE            Short=LIS-1;
DE   AltName: Full=nudF homolog;
else
DE   RecName: Full=Lissencephaly-1 homolog;
end case
case <OC:Vertebrata>
GN   Name=PAFAH1B1; Synonyms=LIS1;
else case <OC:Drosophilidae>
GN   Name=Lis-1;
else case <OC:Caenorhabditis>
GN   Name=lis-1;
else case <OC:Eurotiales>
GN   Name=nudF; Synonyms=lis1;
else case <OC:Fungi> and not <OC:Eurotiales>
GN   Name=PAC1; Synonyms=LIS1;
end case
XX
case <OC:Mammalia>
CC   -!- FUNCTION: Positively regulates the activity of the minus-end directed
CC       microtubule motor protein dynein. May enhance dynein-mediated
CC       microtubule sliding by targeting dynein to the microtubule plus end.
CC       Required for several dynein- and microtubule-dependent processes such
CC       as the maintenance of Golgi integrity, the peripheral transport of
CC       microtubule fragments and the coupling of the nucleus and centrosome.
CC       Required during brain development for the proliferation of neuronal
CC       precursors and the migration of newly formed neurons from the
CC       ventricular/subventricular zone toward the cortical plate. Neuronal
CC       migration involves a process called nucleokinesis, whereby migrating
CC       cells extend an anterior process into which the nucleus subsequently
CC       translocates. During nucleokinesis dynein at the nuclear surface may
CC       translocate the nucleus towards the centrosome by exerting force on
CC       centrosomal microtubules. Also required for proper activation of Rho
CC       GTPases and actin polymerization at the leading edge of locomoting
CC       cerebellar neurons and postmigratory hippocampal neurons in response to
CC       calcium influx triggered via NMDA receptors. May also play a role in
CC       other forms of cell locomotion including the migration of fibroblasts
CC       during wound healing. Non-catalytic subunit of an acetylhydrolase
CC       complex which inactivates platelet-activating factor (PAF) by removing
CC       the acetyl group at the SN-2 position.
else case <OC:Vertebrata> and not <OC:Mammalia>
CC   -!- FUNCTION: Positively regulates the activity of the minus-end directed
CC       microtubule motor protein dynein. May enhance dynein-mediated
CC       microtubule sliding by targeting dynein to the microtubule plus end.
CC       Required for several dynein- and microtubule-dependent processes such
CC       as the maintenance of Golgi integrity, the peripheral transport of
CC       microtubule fragments and the coupling of the nucleus and centrosome.
CC       May be required for proliferation of neuronal precursors and neuronal
CC       migration.
else case <OC:Saccharomycotina> or <OC:Cryptococcaceae>
CC   -!- FUNCTION: Positively regulates the activity of the minus-end directed
CC       microtubule motor protein dynein. Plays a central role in positioning
CC       the mitotic spindle at the bud neck during cell division. Targets
CC       cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-
CC       mediated microtubule sliding along the bud cortex and consequently the
CC       movement of the mitotic spindle to the bud neck.
else case <OC:Fungi> and not (<OC:Saccharomycotina> or <OC:Cryptococcaceae>)
CC   -!- FUNCTION: Positively regulates the activity of the minus-end directed
CC       microtubule motor protein dynein. May enhance dynein-mediated
CC       microtubule sliding by targeting dynein to the microtubule plus end.
CC       Required for nuclear migration during vegetative growth as well as
CC       development. Required for retrograde early endosome (EE) transport from
CC       the hyphal tip. Required for localization of dynein to the mitotic
CC       spindle poles. Recruits additional proteins to the dynein complex at
CC       SPBs.
else
CC   -!- FUNCTION: Positively regulates the activity of the minus-end directed
CC       microtubule motor protein dynein. May enhance dynein-mediated
CC       microtubule sliding by targeting dynein to the microtubule plus end.
CC       Required for several dynein- and microtubule-dependent processes.
end case
case <OC:Mammalia>
CC   -!- SUBUNIT: Can self-associate. Interacts with DCX, dynein, dynactin,
CC       IQGAP1, KATNB1, NDE1, NDEL1, NUDC and RSN. Interacts with DISC1, and
CC       this interaction is enhanced by NDEL1. Interacts with DAB1 when DAB1 is
CC       phosphorylated in response to RELN/reelin signaling. Component of
CC       cytosolic PAF-AH IB, which is composed of PAFAH1B1 (alpha), PAFAH1B2
CC       (beta) and PAFAH1B3 (gamma) subunits. Trimer formation is not essential
CC       for the catalytic activity of the enzyme which is contributed solely by
CC       the PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits.
else case <OC:Vertebrata>
CC   -!- SUBUNIT: Can self-associate. Interacts with dynein, dynactin, @gn(NDE1)
CC       and @gn(NDEL1).
else case <OC:Eurotiales>
CC   -!- SUBUNIT: Self-associates. Interacts with nudE and dynein.
else case <OC:Fungi> and not <OC:Eurotiales>
CC   -!- SUBUNIT: Self-associates. Interacts with @gn(NDL1) and dynein.
else case <OC:Nematoda>
CC   -!- SUBUNIT: May be a component of a dynein regulatory complex composed of
CC       at least lis-1 and nud-2. Interacts with nud-2.
end case
case <OC:Mammalia>
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton,
CC       microtubule organizing center, centrosome. Cytoplasm, cytoskeleton,
CC       spindle. Nucleus membrane. Note=Localizes to the plus end of
CC       microtubules and to the centrosome. May localize to the nuclear
CC       membrane. Redistributes to axons during neuronal development. Also
CC       localizes to the microtubules of the manchette in elongating spermatids
CC       and to the meiotic spindle in spermatocytes.
else case <OC:Saccharomycotina> or <OC:Cryptococcaceae>
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton,
CC       spindle pole. Note=Localizes to the plus ends of microtubules and the
CC       mitotic spindle poles.
else case <OC:Fungi> and not (<OC:Saccharomycotina> or <OC:Cryptococcaceae>)
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton,
CC       spindle pole. Note=Localizes to the plus ends of microtubules at the
CC       hyphal tip and the mitotic spindle poles.
else case not <OC:Fungi>
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton,
CC       microtubule organizing center, centrosome. Note=Localizes to the plus
CC       end of microtubules and to the centrosome.
end case
case <Feature:PS50896>
CC   -!- DOMAIN: Dimerization mediated by the LisH domain may be required to
CC       activate dynein.
end case
CC   -!- SIMILARITY: Belongs to the WD repeat LIS1/nudF family.
XX
DR   PROSITE; PS50896; LISH; 0-1; trigger=yes
DR   PROSITE; PS00678; WD_REPEATS_1; 1-6; trigger=no
DR   PROSITE; PS50082; WD_REPEATS_2; 1-8; trigger=no
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1; trigger=no
DR   Pfam; PF08513; LisH; 1; trigger=no
DR   Pfam; PF00400; WD40; 7; trigger=no
DR   PRINTS; PR00320; GPROTEINBRPT; 1; trigger=no
DR   PIRSF; PIRSF037647; Dynein_regulator_Lis1; 1; trigger=no
DR   General; Coiled_coil; -; 1-unlimited; trigger=yes
DR   REP; Repeat_WD40; WD40; 7-8; trigger=yes
XX
KW   Cell cycle
KW   Cell division
KW   Coiled coil
KW   Cytoplasm
KW   Cytoskeleton
KW   Microtubule
KW   Mitosis
KW   Transport
case <OC:Vertebrata>
KW   Developmental protein
KW   Differentiation
KW   Neurogenesis
end case
case <OC:Mammalia>
KW   Lipid degradation
KW   Lipid metabolism
KW   Membrane
KW   Nucleus
end case
XX
GO   GO:0005737; C:cytoplasm
GO   GO:0005875; C:microtubule associated complex
GO   GO:0070840; F:dynein complex binding
GO   GO:0051012; P:microtubule sliding
GO   GO:0000132; P:establishment of mitotic spindle orientation
GO   GO:0007017; P:microtubule-based process
case <OC:Vertebrata>
GO   GO:0007399; P:nervous system development
end case
XX
FT   From: LIS1_HUMAN (P43034)
case <OC:Vertebrata>
FT   INIT_MET        1
FT                   /note="Removed"
FT   Condition: M
end case
case <OC:Mammalia>
FT   REGION          Nter..102
FT                   /note="Interaction with NDEL1"
FT   REGION          Nter..66
FT                   /note="Interaction with NDE1"
FT   REGION          Nter..38
FT                   /note="Required for self-association and interaction with
FT                   PAFAH1B2 and PAFAH1B3"
FT   REGION          83..Cter
FT                   /note="Interaction with dynein and dynactin"
FT   REGION          367..409
FT                   /note="Interaction with DCX"
FT   REGION          388..Cter
FT                   /note="Interaction with NDEL1"
end case
XX
Size: 390-529;
Related: None;
Template: P43034; Q00664;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: in ASPCL, CHAGB, DANRE, NEUCR, PARTE, PENCW, PENMQ, PODAN, POSPM,
 SALSA, SORMK, UNCRE
Plasmid: None
Comments: None
XX
# Revision 1.12 2019/11/20
//