AC MF_03143; DC Protein; auto TR HAMAP; MF_03143; -; 1; level=0 XX Names: Pentafunct_AroM XX ID ARO1 DE RecName: Full=Pentafunctional AROM polypeptide; DE Includes: DE RecName: Full=3-dehydroquinate synthase; DE Short=DHQS; DE EC=4.2.3.4; DE Includes: DE RecName: Full=3-phosphoshikimate 1-carboxyvinyltransferase; DE EC=2.5.1.19; DE AltName: Full=5-enolpyruvylshikimate-3-phosphate synthase; DE Short=EPSP synthase; DE Short=EPSPS; DE Includes: DE RecName: Full=Shikimate kinase; DE Short=SK; DE EC=2.7.1.71; DE Includes: DE RecName: Full=3-dehydroquinate dehydratase; DE Short=3-dehydroquinase; DE EC=4.2.1.10; DE Includes: DE RecName: Full=Shikimate dehydrogenase; DE EC=1.1.1.25; case GN Name=aroM; else case GN Name=ARO1; else case GN Name=aro1; else case GN Name=aro-1; end case XX CC -!- FUNCTION: The AROM polypeptide catalyzes 5 consecutive enzymatic CC reactions in prechorismate polyaromatic amino acid biosynthesis. CC -!- CATALYTIC ACTIVITY: CC Reaction=7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3- CC dehydroquinate + phosphate; Xref=Rhea:RHEA:21968, ChEBI:CHEBI:32364, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58394; EC=4.2.3.4; CC -!- CATALYTIC ACTIVITY: CC Reaction=3-dehydroquinate = 3-dehydroshikimate + H2O; CC Xref=Rhea:RHEA:21096, ChEBI:CHEBI:15377, ChEBI:CHEBI:16630, CC ChEBI:CHEBI:32364; EC=4.2.1.10; CC -!- CATALYTIC ACTIVITY: CC Reaction=NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH; CC Xref=Rhea:RHEA:17737, ChEBI:CHEBI:15378, ChEBI:CHEBI:16630, CC ChEBI:CHEBI:36208, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.25; CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + shikimate = 3-phosphoshikimate + ADP + H(+); CC Xref=Rhea:RHEA:13121, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:36208, ChEBI:CHEBI:145989, ChEBI:CHEBI:456216; CC EC=2.7.1.71; CC -!- CATALYTIC ACTIVITY: CC Reaction=3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1- CC carboxyvinyl)-3-phosphoshikimate + phosphate; Xref=Rhea:RHEA:21256, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:57701, ChEBI:CHEBI:58702, CC ChEBI:CHEBI:145989; EC=2.5.1.19; CC -!- COFACTOR: CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; CC Note=Binds 2 Zn(2+) ions per subunit.; CC -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; CC chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step CC 2/7. CC -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; CC chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step CC 3/7. CC -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; CC chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step CC 4/7. CC -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; CC chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step CC 5/7. CC -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; CC chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step CC 6/7. CC -!- SUBUNIT: Homodimer. CC -!- SUBCELLULAR LOCATION: Cytoplasm. CC -!- SIMILARITY: In the N-terminal section; belongs to the sugar phosphate CC cyclases superfamily. Dehydroquinate synthase family. CC -!- SIMILARITY: In the 2nd section; belongs to the EPSP synthase family. CC -!- SIMILARITY: In the 3rd section; belongs to the shikimate kinase family. CC -!- SIMILARITY: In the 4th section; belongs to the type-I 3-dehydroquinase CC family. CC -!- SIMILARITY: In the C-terminal section; belongs to the shikimate CC dehydrogenase family. XX DR PROSITE; PS01028; DEHYDROQUINASE_I; 1; trigger=no DR PROSITE; PS00104; EPSP_SYNTHASE_1; 1; trigger=no DR PROSITE; PS00885; EPSP_SYNTHASE_2; 1; trigger=no DR PROSITE; PS01128; SHIKIMATE_KINASE; 1; trigger=no DR Pfam; PF01487; DHquinase_I; 1; trigger=no DR Pfam; PF00275; EPSP_synthase; 1; trigger=no DR Pfam; PF01488; Shikimate_DH; 1; trigger=no DR Pfam; PF08501; Shikimate_dh_N; 1; trigger=no DR Pfam; PF01202; SKI; 1; trigger=no DR Pfam; PF01761; DHQ_synthase; 1; trigger=no DR PRINTS; PR01100; SHIKIMTKNASE; 1; trigger=no DR NCBIfam; TIGR01356; aroA; 1; trigger=no DR NCBIfam; TIGR01357; aroB; 1; trigger=no DR NCBIfam; TIGR01093; aroD; 1; trigger=no DR NCBIfam; TIGR01809; Shik-DH-AROM; 1; trigger=no DR PIRSF; PIRSF001455; DHQ_synth; 1; trigger=no DR PIRSF; PIRSF000514; Pentafunct_AroM; 1; trigger=no XX KW Amino-acid biosynthesis KW Aromatic amino acid biosynthesis KW ATP-binding KW Cytoplasm KW Kinase KW Lyase KW Metal-binding KW Multifunctional enzyme KW NADP KW Nucleotide-binding KW Oxidoreductase KW Transferase KW Zinc XX GO GO:0005737; C:cytoplasm GO GO:0003855; F:3-dehydroquinate dehydratase activity GO GO:0003856; F:3-dehydroquinate synthase activity GO GO:0003866; F:3-phosphoshikimate 1-carboxyvinyltransferase activity GO GO:0005524; F:ATP binding GO GO:0046872; F:metal ion binding GO GO:0004764; F:shikimate 3-dehydrogenase (NADP+) activity GO GO:0004765; F:shikimate kinase activity GO GO:0009073; P:aromatic amino acid family biosynthetic process XX FT From: ARO1_EMENI (P07547) FT BINDING 44..46 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT Condition: D-[TSDQ]-[NRT] FT BINDING 81..84 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT Condition: E-x(2)-K FT BINDING 114..116 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT Condition: G-G-[VI] FT BINDING 139..140 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT Condition: T-[TS] FT BINDING 179..182 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT Condition: [FYW]-[LI]-x-[TS] FT BINDING 870..877 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT Condition: G-M-R-[GA]-[AST]-G-K-[ST] FT REGION Nter..384 FT /note="3-dehydroquinate synthase" FT BINDING 194..197 FT /ligand="7-phospho-2-dehydro-3-deoxy-D-arabino- FT heptonate" FT /ligand_id="ChEBI:CHEBI:58394" FT Condition: E-[VIL]-[IV]-K FT BINDING 264..268 FT /ligand="7-phospho-2-dehydro-3-deoxy-D-arabino- FT heptonate" FT /ligand_id="ChEBI:CHEBI:58394" FT Condition: R-[NT]-[LI]-[LV]-N FT REGION 397..842 FT /note="EPSP synthase" FT REGION 863..1055 FT /note="Shikimate kinase" FT REGION 1056..1276 FT /note="3-dehydroquinase" FT REGION 1289..Cter FT /note="Shikimate dehydrogenase" FT ACT_SITE 260 FT /note="Proton acceptor; for 3-dehydroquinate synthase FT activity" FT Condition: E FT ACT_SITE 275 FT /note="Proton acceptor; for 3-dehydroquinate synthase FT activity" FT Condition: H FT ACT_SITE 824 FT /note="For EPSP synthase activity" FT Condition: C FT ACT_SITE 1179 FT /note="Proton acceptor; for 3-dehydroquinate dehydratase FT activity" FT Condition: H FT ACT_SITE 1207 FT /note="Schiff-base intermediate with substrate; for 3- FT dehydroquinate dehydratase activity" FT Condition: [KR] FT BINDING 194 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_note="catalytic" FT Condition: E FT BINDING 271 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_note="catalytic" FT Condition: H FT BINDING 287 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_note="catalytic" FT Condition: H FT BINDING 119 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT Condition: D FT BINDING 130 FT /ligand="7-phospho-2-dehydro-3-deoxy-D-arabino- FT heptonate" FT /ligand_id="ChEBI:CHEBI:58394" FT Condition: R FT BINDING 146 FT /ligand="7-phospho-2-dehydro-3-deoxy-D-arabino- FT heptonate" FT /ligand_id="ChEBI:CHEBI:58394" FT Condition: D FT BINDING 152 FT /ligand="7-phospho-2-dehydro-3-deoxy-D-arabino- FT heptonate" FT /ligand_id="ChEBI:CHEBI:58394" FT Condition: K FT BINDING 161 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT Condition: K FT BINDING 162 FT /ligand="7-phospho-2-dehydro-3-deoxy-D-arabino- FT heptonate" FT /ligand_id="ChEBI:CHEBI:58394" FT Condition: N FT BINDING 190 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT Condition: N FT BINDING 250 FT /ligand="7-phospho-2-dehydro-3-deoxy-D-arabino- FT heptonate" FT /ligand_id="ChEBI:CHEBI:58394" FT Condition: K FT BINDING 271 FT /ligand="7-phospho-2-dehydro-3-deoxy-D-arabino- FT heptonate" FT /ligand_id="ChEBI:CHEBI:58394" FT Condition: H FT BINDING 287 FT /ligand="7-phospho-2-dehydro-3-deoxy-D-arabino- FT heptonate" FT /ligand_id="ChEBI:CHEBI:58394" FT Condition: H FT BINDING 356 FT /ligand="7-phospho-2-dehydro-3-deoxy-D-arabino- FT heptonate" FT /ligand_id="ChEBI:CHEBI:58394" FT Condition: K XX Size: 1523-1715; Related: MF_00109; MF_00110; MF_00210; MF_00214; MF_00222; Template: P07547; P08566; Scope: Eukaryota; Fungi Fusion: Nter: None Cter: None Duplicate: in LODEL, PENMQ Plasmid: None Comments: None XX # Revision 1.15 2023/06/01 //