AC   MF_03146;
DC   Protein; auto
c?   <OC:Eukaryota>
TR   HAMAP; MF_01116; -; 1; level=0
XX
Names: TSR3_euk
XX
ID   TSR3
DE   RecName: Full=18S rRNA aminocarboxypropyltransferase;
DE            EC=2.5.1.-;
case <OC:Fungi>
GN   Name=TSR3;
end case
XX
case <OC:Vertebrata>
CC   -!- FUNCTION: Aminocarboxypropyltransferase that catalyzes the
CC       aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248)
CC       in 18S rRNA. It constitutes the last step in biosynthesis of the
CC       hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine
CC       (m1acp3-Psi) conserved in eukaryotic 18S rRNA.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-
CC         L-methionine = H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-
CC         carboxypropyl]pseudouridine(1248) in human 18S rRNA + S-methyl-5'-
CC         thioadenosine; Xref=Rhea:RHEA:63292, Rhea:RHEA-COMP:11639, Rhea:RHEA-
CC         COMP:16308, ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:74890, ChEBI:CHEBI:146234;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63293;
else case <OC:Fungi>
CC   -!- FUNCTION: Aminocarboxypropyltransferase that catalyzes the
CC       aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191)
CC       in 18S rRNA. It constitutes the last step in biosynthesis of the
CC       hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine
CC       (m1acp3-Psi) conserved in eukaryotic 18S rRNA.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-
CC         L-methionine = H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-
CC         carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-
CC         thioadenosine; Xref=Rhea:RHEA:63300, Rhea:RHEA-COMP:13852, Rhea:RHEA-
CC         COMP:16309, ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:74890, ChEBI:CHEBI:146234;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63301;
else
CC   -!- FUNCTION: Aminocarboxypropyltransferase that catalyzes the
CC       aminocarboxypropyl transfer on pseudouridine in 18S rRNA. It
CC       constitutes the last step in biosynthesis of the hypermodified N1-
CC       methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an N(1)-methylpseudouridine in 16S/18S rRNA + S-adenosyl-L-
CC         methionine = H(+) + N(1)-methyl-N(3)[(3S)-3-amino-3-
CC         carboxypropyl]pseudouridine in 16S/18S rRNA + S-methyl-5'-
CC         thioadenosine; Xref=Rhea:RHEA:63296, Rhea:RHEA-COMP:11634, Rhea:RHEA-
CC         COMP:16310, ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:74890, ChEBI:CHEBI:146234;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63297;
end case
case <OC:Vertebrata>
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
else case <OC:Fungi>
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
end case
CC   -!- SIMILARITY: Belongs to the TDD superfamily. TSR3 family.
XX
DR   Pfam; PF04034; Ribo_biogen_C; 1; trigger=no
DR   Pfam; PF04068; RLI; 1; trigger=no
XX
case <OC:Vertebrata> or <OC:Fungi>
KW   Cytoplasm
end case
case <OC:Fungi>
KW   Nucleus
end case
KW   Ribosome biogenesis
KW   S-adenosyl-L-methionine
KW   Transferase
KW   rRNA processing
XX
case <OC:Vertebrata> or <OC:Fungi>
GO   GO:0005737; C:cytoplasm
end case
case <OC:Fungi>
GO   GO:0005634; C:nucleus
end case
GO   GO:1904047; F:S-adenosyl-L-methionine binding
GO   GO:0006364; P:rRNA processing
GO   GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis
XX
FT   From: TSR3_YEAST (Q12094)
FT   BINDING         62
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: [ST]
FT   BINDING         110
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: [VIL]
FT   BINDING         133
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: [LI]
FT   BINDING         148
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: [WY]
XX
Size: 247-421;
Related: None;
Template: Q12094; Q9UJK0;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.10 2022/11/19
//