AC   MF_03150;
DC   Protein; auto
c?   <OC:Eukaryota>
TR   HAMAP; MF_00120; -; 1; level=0
XX
Names: GatA_euk
XX
ID   GATA
case <OC:Viridiplantae>
DE   RecName: Full=Glutamyl-tRNA(Gln) amidotransferase subunit A, chloroplastic/mitochondrial;
DE            Short=Glu-AdT subunit A;
DE            EC=6.3.5.7;
else case <OC:Vertebrata>
DE   RecName: Full=Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial;
DE            Short=Glu-AdT subunit A;
DE            EC=6.3.5.7;
DE   AltName: Full=Glutaminyl-tRNA synthase-like protein 1;
else
DE   RecName: Full=Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial;
DE            Short=Glu-AdT subunit A;
DE            EC=6.3.5.7;
end case
case <OC:Vertebrata>
GN   Name=QRSL1;
else case <OC:Saccharomycotina>
GN   Name=HER2;
else case <OC:Viridiplantae>
GN   Name=GATA;
else case <OC:Insecta>
GN   Name=GatA;
end case
XX
case <OC:Viridiplantae>
CC   -!- FUNCTION: Allows the formation of correctly charged Gln-tRNA(Gln)
CC       through the transamidation of misacylated Glu-tRNA(Gln) in chloroplasts
CC       and mitochondria. The reaction takes place in the presence of glutamine
CC       and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
else
CC   -!- FUNCTION: Allows the formation of correctly charged Gln-tRNA(Gln)
CC       through the transamidation of misacylated Glu-tRNA(Gln) in the
CC       mitochondria. The reaction takes place in the presence of glutamine and
CC       ATP through an activated gamma-phospho-Glu-tRNA(Gln).
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) +
CC         L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate;
CC         Xref=Rhea:RHEA:17521, Rhea:RHEA-COMP:9681, Rhea:RHEA-COMP:9684,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58359,
CC         ChEBI:CHEBI:78520, ChEBI:CHEBI:78521, ChEBI:CHEBI:456216; EC=6.3.5.7;
case <OC:Vertebrata>
CC   -!- SUBUNIT: Subunit of the heterotrimeric GatCAB amidotransferase (AdT)
CC       complex, composed of A (@gn(QRSL1)), B (@gn(GATB)) and C (@gn(GATC))
CC       subunits.
else case <OC:Saccharomycotina>
CC   -!- SUBUNIT: Subunit of the heterotrimeric GatFAB amidotransferase (AdT)
CC       complex, composed of A, B and F subunits.
else
CC   -!- SUBUNIT: Subunit of the heterotrimeric GatCAB amidotransferase (AdT)
CC       complex, composed of A, B and C subunits.
end case
case <OC:Viridiplantae>
CC   -!- SUBCELLULAR LOCATION: Mitochondrion. Plastid, chloroplast stroma.
else
CC   -!- SUBCELLULAR LOCATION: Mitochondrion.
end case
case <OC:Viridiplantae>
CC   -!- MISCELLANEOUS: This protein may be expected to contain an N-terminal
CC       transit peptide but none has been predicted.
end case
CC   -!- SIMILARITY: Belongs to the amidase family. GatA subfamily.
XX
DR   PROSITE; PS00571; AMIDASES; 1; trigger=no
DR   Pfam; PF01425; Amidase; 1; trigger=no
DR   NCBIfam; TIGR00132; GatA; 1; trigger=no
XX
case <OC:Viridiplantae>
KW   Chloroplast
KW   Plastid
end case
KW   Mitochondrion
KW   ATP-binding
KW   Ligase
KW   Nucleotide-binding
KW   Protein biosynthesis
XX
case <OC:Viridiplantae>
GO   GO:0009507; C:chloroplast
end case
GO   GO:0005739; C:mitochondrion
GO   GO:0030956; C:glutamyl-tRNA(Gln) amidotransferase complex
GO   GO:0050567; F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
GO   GO:0016884; F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor
GO   GO:0070681; P:glutaminyl-tRNAGln biosynthesis via transamidation
GO   GO:0032543; P:mitochondrial translation
XX
FT   From: GATA_HUMAN (Q9H0R6)
FT   ACT_SITE        76
FT                   /note="Charge relay system"
FT   Condition: K
FT   ACT_SITE        171
FT                   /note="Charge relay system"
FT   Condition: S
FT   ACT_SITE        195
FT                   /note="Acyl-ester intermediate"
FT   Condition: S
XX
Size: 450-550;
Related: None;
Template: Q9H0R6; Q9LI77;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.10 2023/06/01
//