AC MF_03153; DC Protein; auto TR HAMAP; MF_03153; -; 1; level=0 XX Names: U1_C XX ID RU1C DE RecName: Full=U1 small nuclear ribonucleoprotein C; DE Short=U1 snRNP C; DE Short=U1-C; DE Short=U1C; case GN Name=SNRPC; else case GN Name=snRNP-U1-C; else case GN Name=snrpC; else case GN Name=YHC1; end case XX case or CC -!- FUNCTION: Component of the spliceosomal U1 snRNP, which is essential CC for recognition of the pre-mRNA 5' splice-site and the subsequent CC assembly of the spliceosome. SNRPC/U1-C is directly involved in initial CC 5' splice-site recognition for both constitutive and regulated CC alternative splicing. The interaction with the 5' splice-site seems to CC precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates CC commitment or early (E) complex formation by stabilizing the base CC pairing of the 5' end of the U1 snRNA and the 5' splice-site region. CC -!- SUBUNIT: U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, CC SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric CC protein ring on the Sm site of the small nuclear RNA to form the core CC snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, CC SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the CC 5' splice-site region of the pre-mRNA. else CC -!- FUNCTION: Component of the spliceosomal U1 snRNP, which is essential CC for recognition of the pre-mRNA 5' splice-site and the subsequent CC assembly of the spliceosome. U1-C is directly involved in initial 5' CC splice-site recognition for both constitutive and regulated alternative CC splicing. The interaction with the 5' splice-site seems to precede CC base-pairing between the pre-mRNA and the U1 snRNA. Stimulates CC commitment or early (E) complex formation by stabilizing the base CC pairing of the 5' end of the U1 snRNA and the 5' splice-site region. CC -!- SUBUNIT: U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, CC D3, E, F and G that assemble in a heptameric protein ring on the Sm CC site of the small nuclear RNA to form the core snRNP, and at least 3 U1 CC snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 CC snRNA and the 5' splice-site region of the pre-mRNA. end case CC -!- SUBCELLULAR LOCATION: Nucleus. CC -!- SIMILARITY: Belongs to the U1 small nuclear ribonucleoprotein C family. XX DR PROSITE; PS50171; ZF_MATRIN; 1; trigger=yes DR Pfam; PF06220; zf-U1; 1; trigger=no DR PIRSF; PIRSF037969; U1_snRNP-C; 1; trigger=no XX KW Metal-binding KW Nucleus KW Ribonucleoprotein KW RNA-binding KW Zinc KW Zinc-finger XX GO GO:0000243; C:commitment complex GO GO:0005685; C:U1 snRNP GO GO:0071004; C:U2-type prespliceosome GO GO:0003729; F:mRNA binding GO GO:0030619; F:U1 snRNA binding GO GO:0008270; F:zinc ion binding GO GO:0000395; P:mRNA 5'-splice site recognition GO GO:0000387; P:spliceosomal snRNP assembly XX FT None XX Size: 122-242; Related: None; Template: P09234; Q05900; Scope: Eukaryota Fusion: Nter: None Cter: None Duplicate: in PUCGT, SORBI Plasmid: None Comments: None XX # Revision 1.9 2019/12/10 //