AC   MF_03157;
DC   Protein; auto
c?   <OC:Eukaryota>
TR   HAMAP; MF_01965; -; 1; level=0
XX
Names: NADHX_dehydratase_euk
XX
ID   NNRD
case <OC:Mammalia>
DE   RecName: Full=ATP-dependent (S)-NAD(P)H-hydrate dehydratase;
DE            EC=4.2.1.93;
DE   AltName: Full=ATP-dependent NAD(P)HX dehydratase;
DE   AltName: Full=Carbohydrate kinase domain-containing protein;
GN   Name=CARKD;
else
DE   RecName: Full=ATP-dependent (S)-NAD(P)H-hydrate dehydratase;
DE            EC=4.2.1.93;
DE   AltName: Full=ATP-dependent NAD(P)HX dehydratase;
end case
XX
CC   -!- FUNCTION: Catalyzes the dehydration of the S-form of NAD(P)HX at the
CC       expense of ATP, which is converted to ADP. Together with NAD(P)HX
CC       epimerase, which catalyzes the epimerization of the S- and R-forms, the
CC       enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of
CC       NAD(P)H that is a result of enzymatic or heat-dependent hydration.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6S)-NADHX + ATP = ADP + H(+) + NADH + phosphate;
CC         Xref=Rhea:RHEA:19017, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57945, ChEBI:CHEBI:64074,
CC         ChEBI:CHEBI:456216; EC=4.2.1.93;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6S)-NADPHX + ATP = ADP + H(+) + NADPH + phosphate;
CC         Xref=Rhea:RHEA:32231, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57783, ChEBI:CHEBI:64076,
CC         ChEBI:CHEBI:456216; EC=4.2.1.93;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
case <OC:Fungi>
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
else case <OC:Mammalia>
CC   -!- SUBCELLULAR LOCATION: Mitochondrion.
end case
case <OC:Mammalia> and not <AnyFeature:TransitM>
CC   -!- MISCELLANEOUS: This protein may be expected to contain an N-terminal
CC       transit peptide but none has been predicted.
end case
CC   -!- SIMILARITY: Belongs to the NnrD/CARKD family.
XX
DR   PROSITE; PS01049; YJEF_C_1; 1; trigger=no
DR   PROSITE; PS01050; YJEF_C_2; 1; trigger=no
DR   PROSITE; PS51383; YJEF_C_3; 1; trigger=yes
DR   Pfam; PF01256; Carb_kinase; 1; trigger=no
DR   NCBIfam; TIGR00196; YjeF_C; 1; trigger=no
case <OC:Mammalia>
DR   General; TransitM; -; 0-1; trigger=yes
end case
XX
KW   ATP-binding
KW   Lyase
KW   NAD
KW   Nucleotide-binding
KW   Phosphoprotein
case <OC:Fungi>
KW   Cytoplasm
else case <OC:Mammalia>
KW   Mitochondrion
end case
XX
GO   GO:0047453; F:ATP-dependent NAD(P)H-hydrate dehydratase activity
GO   GO:0046496; P:nicotinamide nucleotide metabolic process
case <OC:Fungi>
GO   GO:0005737; C:cytoplasm
else case <OC:Mammalia>
GO   GO:0005739; C:mitochondrion
end case
XX
FT   From: NNRD_BACSU (P94368)
FT   BINDING         186..190
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: K-x(4)
FT   BINDING         206..215
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: x(7)-G-x-G
FT   BINDING         149..155
FT                   /ligand="(6S)-NADPHX"
FT                   /ligand_id="ChEBI:CHEBI:64076"
FT   Condition: x(3)-E-x(3)
FT   BINDING         104
FT                   /ligand="(6S)-NADPHX"
FT                   /ligand_id="ChEBI:CHEBI:64076"
FT   BINDING         216
FT                   /ligand="(6S)-NADPHX"
FT                   /ligand_id="ChEBI:CHEBI:64076"
FT   Condition: D
XX
Size: 295-413;
Related: None;
Template: P36059; Q9CZ42; P94368;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: in PUCGT
Plasmid: None
Comments: None
XX
# Revision 1.14 2023/06/01
//