AC   MF_03159;
DC   Protein; auto
c?   <OC:Eukaryota>
TR   HAMAP; MF_01966; -; 1; level=0
XX
Names: NADHX_epimerase_euk
XX
ID   NNRE
case <OC:Vertebrata>
DE   RecName: Full=NAD(P)H-hydrate epimerase;
DE            EC=5.1.99.6;
DE   AltName: Full=Apolipoprotein A-I-binding protein;
DE            Short=AI-BP;
DE   AltName: Full=NAD(P)HX epimerase;
GN   Name=APOA1BP; Synonyms=AIBP;
else
DE   RecName: Full=NAD(P)H-hydrate epimerase;
DE            EC=5.1.99.6;
DE   AltName: Full=NAD(P)HX epimerase;
end case
XX
case <OC:Mammalia>
CC   -!- FUNCTION: Catalyzes the epimerization of the S- and R-forms of
CC       NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or
CC       heat-dependent hydration. This is a prerequisite for the S-specific
CC       NAD(P)H-hydrate dehydratase to allow the repair of both epimers of
CC       NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to
CC       high-density lipoprotein (HDL) and thereby regulates angiogenesis.
else
CC   -!- FUNCTION: Catalyzes the epimerization of the S- and R-forms of
CC       NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or
CC       heat-dependent hydration. This is a prerequisite for the S-specific
CC       NAD(P)H-hydrate dehydratase to allow the repair of both epimers of
CC       NAD(P)HX.
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6R)-NADHX = (6S)-NADHX; Xref=Rhea:RHEA:32215,
CC         ChEBI:CHEBI:64074, ChEBI:CHEBI:64075; EC=5.1.99.6;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6R)-NADPHX = (6S)-NADPHX; Xref=Rhea:RHEA:32227,
CC         ChEBI:CHEBI:64076, ChEBI:CHEBI:64077; EC=5.1.99.6;
CC   -!- COFACTOR:
CC       Name=K(+); Xref=ChEBI:CHEBI:29103;
CC       Note=Binds 1 potassium ion per subunit.;
case <OC:Fungi>
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Mitochondrion.
else case <OC:Mammalia>
CC   -!- SUBUNIT: Homodimer. Interacts with @gn(APOA1) and @gn(APOA2).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion. Secreted. Note=In sperm, secretion
CC       gradually increases during capacitation.
CC   -!- PTM: Undergoes physiological phosphorylation during sperm capacitation,
CC       downstream to PKA activation.
else case <OC:Vertebrata> and not <OC:Mammalia>
CC   -!- SUBCELLULAR LOCATION: Mitochondrion. Secreted.
end case
case <OC:Vertebrata> and not <AnyFeature:TransitM>
CC   -!- MISCELLANEOUS: This protein may be expected to contain an N-terminal
CC       transit peptide but none has been predicted.
end case
CC   -!- SIMILARITY: Belongs to the NnrE/AIBP family.
XX
DR   PROSITE; PS51385; YJEF_N; 1; trigger=yes
DR   Pfam; PF03853; YjeF_N; 1; trigger=no
DR   NCBIfam; TIGR00197; YjeF_nterm; 1; trigger=no
case <OC:Vertebrata>
DR   General; TransitM; -; 0-1; trigger=yes
end case
XX
KW   Isomerase
KW   Metal-binding
KW   NAD
KW   Nucleotide-binding
KW   Potassium
case <OC:Fungi>
KW   Cytoplasm
KW   Mitochondrion
else case <OC:Vertebrata>
KW   Mitochondrion
KW   Secreted
end case
XX
GO   GO:0052856; F:NADHX epimerase activity
case <OC:Fungi>
GO   GO:0005737; C:cytoplasm
else case <OC:Vertebrata>
GO   GO:0005739; C:mitochondrion
end case
XX
FT   From: NNR_THEMA (Q9X024)
FT   BINDING         52
FT                   /ligand="K(+)"
FT                   /ligand_id="ChEBI:CHEBI:29103"
FT   Condition: [NQ]
FT   BINDING         114
FT                   /ligand="K(+)"
FT                   /ligand_id="ChEBI:CHEBI:29103"
FT   Condition: D
FT   BINDING         150
FT                   /ligand="K(+)"
FT                   /ligand_id="ChEBI:CHEBI:29103"
FT   Condition: [ST]
FT   BINDING         51..55
FT                   /ligand="(6S)-NADPHX"
FT                   /ligand_id="ChEBI:CHEBI:64076"
FT   Condition: x-[NQ]-G-x(2)
FT   BINDING         118..124
FT                   /ligand="(6S)-NADPHX"
FT                   /ligand_id="ChEBI:CHEBI:64076"
FT   BINDING         129
FT                   /ligand="(6S)-NADPHX"
FT                   /ligand_id="ChEBI:CHEBI:64076"
FT   Optional; Condition: Y
FT   BINDING         147
FT                   /ligand="(6S)-NADPHX"
FT                   /ligand_id="ChEBI:CHEBI:64076"
FT   Condition: [DE]
XX
Size: 204-292;
Related: None;
Template: Q9X024; Q8NCW5;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.15 2023/06/01
//