AC   MF_03162;
DC   Protein; auto
c?   <OC:Eukaryota>
TR   HAMAP; MF_03162; -; 1; level=0
XX
Names: RNA_methyltr_E_TRM7
XX
ID   TRM7
DE   RecName: Full=Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase;
DE            EC=2.1.1.205;
DE   AltName: Full=2'-O-ribose RNA methyltransferase TRM7 homolog;
case <OC:Mammalia>
DE   + AltName: Full=Protein ftsJ homolog 1;
end case
case <OC:Saccharomycetales>
GN   Name=TRM7;
end case
case <OC:Mammalia>
GN   Name=FTSJ1;
end case
XX
CC   -!- FUNCTION: Methylates the 2'-O-ribose of nucleotides at positions 32 and
CC       34 of the tRNA anticodon loop of substrate tRNAs.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine
CC         = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 H(+) +
CC         2 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42396, Rhea:RHEA-
CC         COMP:10246, Rhea:RHEA-COMP:10247, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269,
CC         ChEBI:CHEBI:74445, ChEBI:CHEBI:74495, ChEBI:CHEBI:82748;
CC         EC=2.1.1.205;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.
XX
DR   Pfam; PF01728; FtsJ; 1; trigger=no
DR   PIRSF; PIRSF005461; 23S_rRNA_mtase; 1; trigger=no
XX
KW   Cytoplasm
KW   Methyltransferase
KW   S-adenosyl-L-methionine
KW   Transferase
KW   tRNA processing
XX
GO   GO:0005737; C:cytoplasm
GO   GO:0008175; F:tRNA methyltransferase activity
GO   GO:0002181; P:cytoplasmic translation
GO   GO:0002128; P:tRNA nucleoside ribose methylation
XX
FT   From: TRM7_YEAST (P38238)
FT   ACT_SITE        164
FT                   /note="Proton acceptor"
FT   Condition: K
FT   BINDING         55
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Group: 1; Condition: G
FT   BINDING         57
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Group: 1; Condition: [WF]
FT   BINDING         83
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Group: 1; Condition: D
FT   BINDING         99
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Group: 1; Condition: [DN]
FT   BINDING         124
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Group: 1; Condition: D
XX
Size: 244-534;
Related: MF_01547; MF_03163;
Template: P38238;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: in DROME, PHYIT, TRIVA
Plasmid: None
Comments: None
XX
# Revision 1.10 2022/11/19
//