AC MF_03164; DC Protein; auto c? TR HAMAP; MF_00132; -; 1; level=0 XX Names: Top6A_euk XX ID TOP6A DE RecName: Full=DNA topoisomerase 6 subunit A; DE EC=5.6.2.2; GN Name=TOP6A; XX CC -!- FUNCTION: Component of the DNA topoisomerase VI involved in chromatin CC organization and progression of endoreduplication cycles. Relaxes both CC positive and negative superturns and exhibits a strong decatenase CC activity. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP-dependent breakage, passage and rejoining of double- CC stranded DNA.; EC=5.6.2.2; CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC -!- SUBUNIT: Homodimer. Heterotetramer of two TOP6A and two TOP6B subunits. CC -!- SUBCELLULAR LOCATION: Nucleus. CC -!- SIMILARITY: Belongs to the TOP6A family. XX DR Pfam; PF04406; TP6A_N; 1; trigger=no DR PRINTS; PR01550; TOP6AFAMILY; 1; trigger=no DR PRINTS; PR01552; TPISMRASE6A; 1; trigger=no DR PROSITE; PS50324; SER_RICH; 0-unlimited; trigger=strict XX KW DNA-binding KW Isomerase KW Magnesium KW Metal-binding KW Nucleotide-binding KW Nucleus KW Topoisomerase XX GO GO:0009330; C:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex GO GO:0005634; C:nucleus GO GO:0003677; F:DNA binding GO GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity GO GO:0000287; F:magnesium ion binding GO GO:0006265; P:DNA topological change XX FT From: TOP6A_METJA (Q57815) FT ACT_SITE 103 FT /note="Nucleophile" FT Condition: Y FT BINDING 197 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT Condition: E FT BINDING 249 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT Condition: D XX Size: 340-453; Related: None; Template: Q57815; Q9LZ03; A2XFC1; Scope: Eukaryota; Viridiplantae Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.12 2022/11/19 //