AC   MF_03165;
DC   Protein; auto
c?   <OC:Eukaryota>
TR   HAMAP; MF_00322; -; 1; level=0
XX
Names: Top6B_plant
XX
ID   TOP6B
DE   RecName: Full=DNA topoisomerase 6 subunit B;
DE            EC=5.6.2.2;
GN   Name=TOP6B;
XX
CC   -!- FUNCTION: Component of the DNA topoisomerase VI involved in chromatin
CC       organization and progression of endoreduplication cycles. Relaxes both
CC       positive and negative superturns and exhibits a strong decatenase
CC       activity. The B subunit binds ATP.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2;
CC   -!- SUBUNIT: Homodimer. Heterotetramer of two TOP6A and two TOP6B subunits.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the TOP6B family.
XX
DR   Pfam; PF02518; HATPase_c; 1; trigger=no
DR   Pfam; PF09239; Topo-VIb_trans; 1; trigger=no
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KW   ATP-binding
KW   DNA-binding
KW   Isomerase
KW   Nucleotide-binding
KW   Nucleus
KW   Topoisomerase
XX
GO   GO:0009330; C:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
GO   GO:0005634; C:nucleus
GO   GO:0005524; F:ATP binding
GO   GO:0003677; F:DNA binding
GO   GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO   GO:0006265; P:DNA topological change
XX
FT   From: TOP6B_SACSH (O05207)
FT   BINDING         97..98
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: [ST]-[KR]
FT   BINDING         106..113
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: G-x-x-G-[LIV]-G-x-[KSA]
FT   BINDING         42
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: N
FT   BINDING         76
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: D
FT   BINDING         427
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: K
XX
Size: 475-842;
Related: None;
Template: O05207; Q9C5V6; B8BDQ4;
Scope:
 Eukaryota; Viridiplantae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.12 2022/11/19
//