AC   MF_03166;
DC   Protein; auto
c?   <OC:Eukaryota>
TR   HAMAP; MF_00148; -; 1; level=0
XX
Names: UDG_euk
XX
ID   UNG
DE   RecName: Full=Uracil-DNA glycosylase;
DE            Short=UDG;
DE            EC=3.2.2.27;
case <OC:Vertebrata>
GN   Name=UNG; Synonyms=UNG1;
else case <OC:Fungi>
GN   Name=UNG1;
end case
XX
CC   -!- FUNCTION: Excises uracil residues from the DNA which can arise as a
CC       result of misincorporation of dUMP residues by DNA polymerase or due to
CC       deamination of cytosine.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolyzes single-stranded DNA or mismatched double-stranded
CC         DNA and polynucleotides, releasing free uracil.; EC=3.2.2.27;
case <OC:Mammalia>
CC   -!- SUBUNIT: Monomer. Interacts with FAM72A.
end case
CC   -!- SUBCELLULAR LOCATION: Mitochondrion. Nucleus.
CC   -!- SIMILARITY: Belongs to the uracil-DNA glycosylase (UDG) superfamily.
CC       UNG family.
XX
DR   Pfam; PF03167; UDG; 1; trigger=no
DR   NCBIfam; TIGR00628; Ung; 1; trigger=no
DR   PROSITE; PS00130; U_DNA_GLYCOSYLASE; 1; trigger=no
XX
KW   DNA damage
KW   DNA repair
KW   Hydrolase
KW   Nucleus
KW   Mitochondrion
XX
GO   GO:0004844; F:uracil DNA N-glycosylase activity
GO   GO:0006284; P:base-excision repair
GO   GO:0005634; C:nucleus
GO   GO:0005739; C:mitochondrion
XX
FT   From: UNG_ECOLI (P12295)
FT   ACT_SITE        64
FT                   /note="Proton acceptor"
FT   Condition: D
XX
Size: 306-359;
Related: None;
Template: P12295;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.9 2023/06/01
//