AC   MF_03173;
DC   Protein; auto
c?   <OC:Eukaryota>
TR   HAMAP; MF_00039; -; 1; level=0
XX
Names: Adenylate_kinase_AK6_euk
XX
ID   KAD6
case <OC:Vertebrata>
DE   RecName: Full=Adenylate kinase isoenzyme 6;
DE            Short=AK6;
DE            EC=2.7.4.3;
DE   AltName: Full=Coilin-interacting nuclear ATPase protein;
DE   AltName: Full=Dual activity adenylate kinase/ATPase;
DE            Short=AK/ATPase;
GN   Name=AK6; Synonyms=CINAP;
else
DE   RecName: Full=Adenylate kinase isoenzyme 6 homolog;
DE            Short=AK6;
DE            EC=2.7.4.3;
DE   AltName: Full=Dual activity adenylate kinase/ATPase;
DE            Short=AK/ATPase;
end case
XX
case <OC:Vertebrata>
CC   -!- FUNCTION: Broad-specificity nucleoside monophosphate (NMP) kinase that
CC       catalyzes the reversible transfer of the terminal phosphate group
CC       between nucleoside triphosphates and monophosphates. Has also ATPase
CC       activity. Involved in the late cytoplasmic maturation steps of the 40S
CC       ribosomal particles, specifically 18S rRNA maturation. While NMP
CC       activity is not required for ribosome maturation, ATPase activity is.
CC       Associates transiently with small ribosomal subunit protein uS11. ATP
CC       hydrolysis breaks the interaction with uS11. May temporarily remove
CC       uS11 from the ribosome to enable a conformational change of the
CC       ribosomal RNA that is needed for the final maturation step of the small
CC       ribosomal subunit. Its NMP activity may have a role in nuclear energy
CC       homeostasis. May be involved in regulation of Cajal body (CB)
CC       formation.
else
CC   -!- FUNCTION: Broad-specificity nucleoside monophosphate (NMP) kinase that
CC       catalyzes the reversible transfer of the terminal phosphate group
CC       between nucleoside triphosphates and monophosphates. Has also ATPase
CC       activity. Involved in the late cytoplasmic maturation steps of the 40S
CC       ribosomal particles, specifically 18S rRNA maturation. While NMP
CC       activity is not required for ribosome maturation, ATPase activity is.
CC       Associates transiently with small ribosomal subunit protein uS11. ATP
CC       hydrolysis breaks the interaction with uS11. May temporarily remove
CC       uS11 from the ribosome to enable a conformational change of the
CC       ribosomal RNA that is needed for the final maturation step of the small
CC       ribosomal subunit. Its NMP activity may have a role in nuclear energy
CC       homeostasis.
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=AMP + ATP = 2 ADP; Xref=Rhea:RHEA:12973, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=2.7.4.3;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
case <OC:Vertebrata>
CC   -!- SUBUNIT: Monomer and homodimer. Interacts with small ribosomal subunit
CC       protein uS11. Not a structural component of 43S pre-ribosomes, but
CC       transiently interacts with them by binding to uS11. Interacts with COIL
CC       (via C-terminus).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleoplasm. Nucleus, Cajal
CC       body. Note=Displays widespread diffuse nucleoplasmic distribution but
CC       not detected in nucleoli. Detected in Cajal bodies but not in all
CC       cells.
else case <OC:Metazoa>
CC   -!- SUBUNIT: Monomer and homodimer. Interacts with small ribosomal subunit
CC       protein uS11. Not a structural component of 43S pre-ribosomes, but
CC       transiently interacts with them by binding to uS11.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
else
CC   -!- SUBUNIT: Interacts with small ribosomal subunit protein uS11. Not a
CC       structural component of 43S pre-ribosomes, but transiently interacts
CC       with them by binding to uS11.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
end case
CC   -!- SIMILARITY: Belongs to the adenylate kinase family. AK6 subfamily.
XX
DR   Pfam; PF01202; SKI; 0-1; trigger=no
DR   PRINTS; PR01100; SHIKIMTKNASE; 0-1; trigger=no
XX
KW   ATP-binding
KW   Kinase
KW   Nucleotide-binding
KW   Transferase
KW   Cytoplasm
KW   Ribosome biogenesis
KW   Nucleus
KW   rRNA processing
XX
case <OC:Vertebrata>
GO   GO:0015030; C:Cajal body
end case
GO   GO:0005737; C:cytoplasm
GO   GO:0005634; C:nucleus
GO   GO:0004017; F:adenylate kinase activity
GO   GO:0016887; F:ATP hydrolysis activity
GO   GO:0042274; P:ribosomal small subunit biogenesis
XX
FT   From: KAD6_HUMAN (Q9Y3D8)
FT   REGION          33..56
FT                   /note="NMPbind"
FT   REGION          108..118
FT                   /note="LID"
FT   BINDING         13
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: G
FT   BINDING         15
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: G
FT   BINDING         16
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: K
FT   BINDING         17
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: [ST]
FT   BINDING         18
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: [STIVY]
FT   BINDING         109
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: R
FT   BINDING         148
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: K
XX
Size: 148-248;
Related: None;
Template: Q9Y3D8; Q09527; Q7JYV7;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.12 2023/11/23
//