AC   MF_03177;
DC   Protein; auto
TR   HAMAP; MF_03177; -; 1; level=0
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Names: RRM3
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ID   RRM3
DE   RecName: Full=ATP-dependent DNA helicase RRM3;
DE            EC=3.6.4.12;
DE   AltName: Full=rDNA recombination mutation protein 3;
GN   Name=RRM3;
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CC   -!- FUNCTION: 5' to 3' DNA replicative helicase recruited to paused
CC       replisomes to promote fork progression throughout nonhistone protein-
CC       DNA complexes, naturally occurring impediments that are encountered in
CC       each S phase where replication forks pauses. Required for timely
CC       replication of the telomere and subtelomeric DNA and for wild-type
CC       levels of telomeric silencing. Involved in DNA repair during stalled
CC       replication fork, regulation of fragile sites expression and essential
CC       for genome stability. Plays also a role in mtDNA replication. Has G-
CC       quadruplex (G4) unwinding activity and can suppress G4-induced genome
CC       instability when PIF1 levels are low.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome, telomere.
CC   -!- SIMILARITY: Belongs to the helicase family. PIF1 subfamily.
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DR   Pfam; PF05970; PIF1; 1; trigger=no
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KW   ATP-binding
KW   Chromosome
KW   DNA damage
KW   DNA repair
KW   DNA-binding
KW   Helicase
KW   Hydrolase
KW   Nucleotide-binding
KW   Nucleus
KW   Telomere
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GO   GO:0005657; C:replication fork
GO   GO:0000781; C:chromosome, telomeric region
GO   GO:0005524; F:ATP binding
GO   GO:0043139; F:5'-3' DNA helicase activity
GO   GO:0051880; F:G-quadruplex DNA binding
GO   GO:0006260; P:DNA replication
GO   GO:0006281; P:DNA repair
GO   GO:0000002; P:mitochondrial genome maintenance
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FT   From: RRM3_YEAST (P38766)
FT   BINDING         254..261
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: G-x-A-G-T-G-K-S
FT   DNA_BIND        682..701
FT   Condition: [QH]-x-Y-V-A-[LI]-S-R-[AV]-x(5)-[LIV]-[QERH]-[LIV]-x(2)-F
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Size: 588-761;
Related: MF_03176;
Template: P38766;
Scope:
 Eukaryota; Saccharomycetales
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.9 2022/11/19
//