AC   MF_03189;
DC   Protein; auto
c?   <OC:Eukaryota>
TR   HAMAP; MF_01635; -; 1; level=0
XX
Names: UbiA_COQ2_euk
XX
ID   COQ2
DE   RecName: Full=4-hydroxybenzoate polyprenyltransferase, mitochondrial;
DE            Short=4-HB polyprenyltransferase;
DE            EC=2.5.1.39;
DE   AltName: Full=Para-hydroxybenzoate--polyprenyltransferase;
DE            Short=PHB:PPT;
DE            Short=PHB:polyprenyltransferase;
case <OC:Hominidae> or <OC:Schizosaccharomycetes>
DE   + AltName: Full=4-hydroxybenzoate decaprenyltransferase;
else case <OC:Arabidopsis>
DE   + AltName: Full=4-hydroxybenzoate nonaprenyltransferase;
else case <OC:Saccharomycotina>
DE   + AltName: Full=4-hydroxybenzoate hexaprenyltransferase;
end case
case <OC:Vertebrata> or <OC:Saccharomycotina>
GN   Name=COQ2;
else case <OC:Drosophilidae>
GN   Name=Coq2;
else case <OC:Insecta> or <OC:Dictyostelia>
GN   Name=coq2;
else case <OC:Caenorhabditis>
GN   Name=coq-2;
else case <OC:Schizosaccharomycetes>
GN   Name=ppt1;
else case <OC:Arabidopsis>
GN   Name=PPT1;
end case
XX
case <OC:Hominidae> or <OC:Rodentia>
CC   -!- FUNCTION: Mediates the second step in the final reaction sequence of
CC       coenzyme Q (CoQ) biosynthesis. Catalyzes the prenylation of para-
CC       hydroxybenzoate (PHB) with an all-trans polyprenyl donor (such as all-
CC       trans-decaprenyl diphosphate or trans-nonaprenyl diphosphate). The
CC       length of the polyprenyl side chain varies depending on the species, in
CC       humans, the side chain is comprised of 10 isoprenyls producing CoQ10
CC       (also known as ubiquinone), whereas rodents predominantly generate
CC       CoQ9. However, this specificity is not complete, human tissues have low
CC       amounts of CoQ9 and rodent organs contain some CoQ10. CoQs are vital
CC       molecules that transport electrons from mitochondrial respiratory chain
CC       complexes. CoQs also function as cofactors for uncoupling protein and
CC       play a role as regulators of the extracellularly-induced ceramide-
CC       dependent apoptotic pathway. Regulates mitochondrial permeability
CC       transition pore (mPTP) opening and ROS production (pivotal events in
CC       cell death) in a tissue specific manner.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-hydroxybenzoate + an all-trans-polyprenyl diphosphate = a 4-
CC         hydroxy-3-all-trans-polyprenylbenzoate + diphosphate;
CC         Xref=Rhea:RHEA:44504, Rhea:RHEA-COMP:9514, Rhea:RHEA-COMP:9564,
CC         ChEBI:CHEBI:17879, ChEBI:CHEBI:33019, ChEBI:CHEBI:58914,
CC         ChEBI:CHEBI:78396; EC=2.5.1.39;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44505;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-hydroxybenzoate + all-trans-decaprenyl diphosphate = 4-
CC         hydroxy-3-all-trans-decaprenylbenzoate + diphosphate;
CC         Xref=Rhea:RHEA:44564, ChEBI:CHEBI:17879, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:60721, ChEBI:CHEBI:84503; EC=2.5.1.39;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44565;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-hydroxybenzoate + all-trans-nonaprenyl diphosphate = 4-
CC         hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate;
CC         Xref=Rhea:RHEA:17709, ChEBI:CHEBI:17879, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:58391, ChEBI:CHEBI:84502; EC=2.5.1.39;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17710;
else
CC   -!- FUNCTION: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with
CC       an all-trans polyprenyl group. Mediates the second step in the final
CC       reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the
CC       condensation of the polyisoprenoid side chain with PHB, generating the
CC       first membrane-bound Q intermediate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-hydroxybenzoate + an all-trans-polyprenyl diphosphate = a 4-
CC         hydroxy-3-all-trans-polyprenylbenzoate + diphosphate;
CC         Xref=Rhea:RHEA:44504, Rhea:RHEA-COMP:9514, Rhea:RHEA-COMP:9564,
CC         ChEBI:CHEBI:17879, ChEBI:CHEBI:33019, ChEBI:CHEBI:58914,
CC         ChEBI:CHEBI:78396; EC=2.5.1.39;
end case
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC       protein; Matrix side.
case not <AnyFeature:TransitM>
CC   -!- MISCELLANEOUS: This protein may be expected to contain an N-terminal
CC       transit peptide but none has been predicted.
end case
CC   -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
XX
DR   PROSITE; PS00943; UBIA; 1; trigger=no
DR   Pfam; PF01040; UbiA; 1; trigger=no
DR   NCBIfam; TIGR01474; ubiA_proteo; 1; trigger=no
DR   General; TransitM; -; 0-1; trigger=yes
DR   General; Transmembrane; -; 0-9; trigger=yes
XX
KW   Isoprene biosynthesis
KW   Membrane
KW   Mitochondrion
KW   Mitochondrion inner membrane
KW   Transferase
KW   Transmembrane
KW   Transmembrane helix
KW   Ubiquinone biosynthesis
XX
GO   GO:0005743; C:mitochondrial inner membrane
case <OC:Hominidae> or <OC:Schizosaccharomycetes>
GO   GO:0002083; F:4-hydroxybenzoate decaprenyltransferase activity
else case <OC:Arabidopsis>
GO   GO:0047293; F:4-hydroxybenzoate nonaprenyltransferase activity
else
GO   GO:0002094; F:polyprenyltransferase activity
end case
GO   GO:0008299; P:isoprenoid biosynthetic process
GO   GO:0006744; P:ubiquinone biosynthetic process
XX
Size: 277-490;
Related: None;
Template: P32378; Q96H96; Q66JT7; Q499N4;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.12 2023/06/01
//