AC   MF_03190;
DC   Protein; auto
c?   <OC:Eukaryota>
TR   HAMAP; MF_00472; -; 1; level=0
XX
Names: UbiG_COQ3_euk
XX
ID   COQ3
DE   RecName: Full=Ubiquinone biosynthesis O-methyltransferase, mitochondrial;
DE   AltName: Full=3-demethylubiquinol 3-O-methyltransferase;
DE            EC=2.1.1.64;
DE   AltName: Full=Polyprenyldihydroxybenzoate methyltransferase;
DE            EC=2.1.1.114;
case <OC:Saccharomycotina>
DE   + AltName: Full=3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase;
DE              Short=DHHB methyltransferase;
DE              Short=DHHB-MT;
DE              Short=DHHB-MTase;
DE     AltName: Full=3-demethylubiquinone-6 3-O-methyltransferase;
DE     AltName: Full=Hexaprenyldihydroxybenzoate methyltransferase;
end case
case <OC:Vertebrata> or <OC:Fungi> or <OC:Viridiplantae>
GN   Name=COQ3;
else case <OC:Drosophilidae>
GN   Name=Coq3;
else case <OC:Insecta> or <OC:Dictyostelia>
GN   Name=coq3;
else case <OC:Caenorhabditis>
GN   Name=coq-3;
end case
XX
CC   -!- FUNCTION: O-methyltransferase that catalyzes the 2 O-methylation steps
CC       in the ubiquinone biosynthetic pathway.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-
CC         methionine = 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate +
CC         H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:44452, Rhea:RHEA-
CC         COMP:10930, Rhea:RHEA-COMP:10931, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:64694,
CC         ChEBI:CHEBI:84443; EC=2.1.1.114;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol
CC         + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:44380, Rhea:RHEA-
CC         COMP:9566, Rhea:RHEA-COMP:10914, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17976, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:84422; EC=2.1.1.64;
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
case <OC:Saccharomyces>
CC   -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex, composed of
CC       at least @gn(COQ3), @gn(COQ4), @gn(COQ5), @gn(COQ6), @gn(COQ7) and
CC       @gn(COQ9). Interacts with COQ3.
else case <OC:Vertebrata> or <OC:Fungi> and not <OC:Saccharomyces>
CC   -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex, composed of
CC       at least @gn(COQ3), @gn(COQ4), @gn(COQ5), @gn(COQ6), @gn(COQ7) and
CC       @gn(COQ9).
else
CC   -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex.
end case
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane
CC       protein; Matrix side.
case not <AnyFeature:TransitM>
CC   -!- MISCELLANEOUS: This protein may be expected to contain an N-terminal
CC       transit peptide but none has been predicted.
end case
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. UbiG/COQ3 family.
XX
DR   Pfam; PF08241; Methyltransf_11; 0-1; trigger=no
DR   Pfam; PF13847; Methyltransf_31; 0-1; trigger=no
DR   NCBIfam; TIGR01983; UbiG; 1; trigger=no
DR   General; TransitM; -; 0-1; trigger=yes
XX
KW   Membrane
KW   Methyltransferase
KW   Mitochondrion
KW   Mitochondrion inner membrane
KW   S-adenosyl-L-methionine
KW   Transferase
KW   Ubiquinone biosynthesis
XX
GO   GO:0031314; C:extrinsic component of mitochondrial inner membrane
case <OC:Saccharomycotina>
GO   GO:0061543; F:3-demethylubiquinol-6 3-O-methyltransferase activity
GO   GO:0004395; F:hexaprenyldihydroxybenzoate methyltransferase activity
else case <OC:Hominidae> or <OC:Schizosaccharomycetes>
GO   GO:0044596; F:3-demethylubiquinol-10 3-O-methyltransferase activity
GO   GO:0044595; F:decaprenyldihydroxybenzoate methyltransferase activity
else case <OC:Arabidopsis>
GO   GO:0008689; F:3-demethylubiquinone-9 3-O-methyltransferase activity
GO   GO:0010420; F:3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity
else
GO   GO:0061542; F:3-demethylubiquinol-n 3-O-methyltransferase activity
GO   GO:0010420; F:3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity
end case
GO   GO:0006744; P:ubiquinone biosynthetic process
XX
FT   From: COQ3_YEAST (P27680)
FT   BINDING         68
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: R
FT   BINDING         130
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: G
FT   BINDING         153
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: D
FT   BINDING         196
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
XX
Size: 232-371;
Related: None;
Template: P27680;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: in AEDAE, ANODA, ANOGA, BOVIN, DAPPU, SETIT, SOYBN
Plasmid: None
Comments: None
XX
# Revision 1.14 2023/06/01
//