AC   MF_03191;
DC   Protein; auto
c?   <OC:Eukaryota>
TR   HAMAP; MF_01813; -; 1; level=0
XX
Names: MenG_UbiE_methyltr_euk
XX
ID   COQ5
DE   RecName: Full=2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial;
DE            EC=2.1.1.201;
DE   AltName: Full=Ubiquinone biosynthesis methyltransferase COQ5;
case <OC:Vertebrata> or <OC:Fungi> or <OC:Viridiplantae>
GN   Name=COQ5;
else case <OC:Drosophilidae>
GN   Name=Coq5;
else case <OC:Insecta> or <OC:Dictyostelia>
GN   Name=coq5;
else case <OC:Caenorhabditis>
GN   Name=coq-5;
end case
XX
CC   -!- FUNCTION: Methyltransferase required for the conversion of 2-
CC       polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-
CC       6-methoxy-1,4-benzoquinol (DMQH2).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-
CC         adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl-
CC         1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:28286, Rhea:RHEA-COMP:10858, Rhea:RHEA-COMP:10859,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:84166, ChEBI:CHEBI:84167; EC=2.1.1.201;
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
case <OC:Saccharomyces>
CC   -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex, composed of
CC       at least @gn(COQ3), @gn(COQ4), @gn(COQ5), @gn(COQ6), @gn(COQ7) and
CC       @gn(COQ9). Interacts with COQ3.
else case <OC:Vertebrata> or <OC:Fungi> and not <OC:Saccharomyces>
CC   -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex, composed of
CC       at least @gn(COQ3), @gn(COQ4), @gn(COQ5), @gn(COQ6), @gn(COQ7) and
CC       @gn(COQ9).
else
CC   -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex.
end case
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane
CC       protein; Matrix side.
case not <AnyFeature:TransitM>
CC   -!- MISCELLANEOUS: This protein may be expected to contain an N-terminal
CC       transit peptide but none has been predicted.
end case
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. MenG/UbiE family.
XX
DR   PROSITE; PS51608; SAM_MT_UBIE; 1; trigger=no
DR   PROSITE; PS01183; UBIE_1; 1; trigger=no
DR   PROSITE; PS01184; UBIE_2; 1; trigger=no
DR   Pfam; PF01209; Ubie_methyltran; 1; trigger=no
DR   NCBIfam; TIGR01934; MenG_MenH_UbiE; 1; trigger=no
DR   NCBIfam; TIGR02752; MenG_heptapren; 1; trigger=no
DR   General; TransitM; -; 0-1; trigger=yes
XX
KW   Membrane
KW   Methyltransferase
KW   Mitochondrion
KW   Mitochondrion inner membrane
KW   S-adenosyl-L-methionine
KW   Transferase
KW   Ubiquinone biosynthesis
XX
GO   GO:0031314; C:extrinsic component of mitochondrial inner membrane
case <OC:Saccharomycotina>
GO   GO:0043334; F:2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
else case <OC:Hominidae> or <OC:Schizosaccharomycetes>
GO   GO:0043430; F:2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
else case <OC:Arabidopsis>
GO   GO:0043429; F:2-nonaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
else
GO   GO:0008425; F:2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
end case
GO   GO:0006744; P:ubiquinone biosynthetic process
XX
FT   From: COQ5_YEAST (P49017)
FT   BINDING         179..180
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: [ND]-x
FT   BINDING         122
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: [ST]
FT   BINDING         148
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: D
FT   BINDING         197
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: S
XX
Size: 218-330;
Related: MF_03192!; MF_01982!;
Template: P49017;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.11 2023/06/01
//