AC MF_03199; DC Protein; auto TR HAMAP; MF_03199; -; 1; level=0 XX Names: DHHC_PAT_PFA4 XX ID PFA4 DE RecName: Full=Palmitoyltransferase ; DE EC=2.3.1.225; DE AltName: Full=Protein S-acyltransferase; DE Short=PAT; DE AltName: Full=Protein fatty acyltransferase 4; GN Name=PFA4; XX CC -!- FUNCTION: Mediates the reversible addition of palmitate to target CC proteins, thereby regulating their membrane association and biological CC function. CC -!- CATALYTIC ACTIVITY: CC Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- CC hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- CC COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; CC EC=2.3.1.225; CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass CC membrane protein. CC -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity. CC -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family. PFA4 CC subfamily. XX DR PROSITE; PS50216; DHHC; 1; trigger=yes DR Pfam; PF01529; zf-DHHC; 1; trigger=no DR General; Transmembrane; -; 4; trigger=yes DR ADD_TOPO_DOMAIN; Cytoplasmic; -; 3; trigger=yes DR ADD_TOPO_DOMAIN; Lumenal; -; 2; trigger=yes XX KW Acyltransferase KW Endoplasmic reticulum KW Lipoprotein KW Membrane KW Palmitate KW Transferase KW Transmembrane KW Transmembrane helix XX GO GO:0005789; C:endoplasmic reticulum membrane GO GO:0016409; F:palmitoyltransferase activity GO GO:0019706; F:protein-cysteine S-palmitoyltransferase activity GO GO:0018345; P:protein palmitoylation XX FT From: PFA4_YEAST (Q12006) FT ACT_SITE 108 FT /note="S-palmitoyl cysteine intermediate" FT Condition: C XX Size: 342-486; Related: None; Template: Q12006; J9VJ99; Scope: Eukaryota; Fungi Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.6 2019/11/20 //