AC   MF_03201;
DC   Protein; auto
TR   HAMAP; MF_03201; -; 1; level=0
XX
Names: VLCF_elongase_1
XX
ID   ELOV1
DE   RecName: Full=Elongation of very long chain fatty acids protein 1;
DE            EC=2.3.1.199;
DE   AltName: Full=3-keto acyl-CoA synthase <gene_name>;
DE   AltName: Full=ELOVL fatty acid elongase 1;
DE            Short=ELOVL FA elongase 1;
DE   AltName: Full=Very long chain 3-ketoacyl-CoA synthase 1;
DE   AltName: Full=Very long chain 3-oxoacyl-CoA synthase 1;
GN   Name=ELOVL1;
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case <OC:Mammalia>
CC   -!- FUNCTION: Catalyzes the first and rate-limiting reaction of the four
CC       reactions that constitute the long-chain fatty acids elongation cycle.
CC       This endoplasmic reticulum-bound enzymatic process allows the addition
CC       of 2 carbons to the chain of long- and very long-chain fatty acids
CC       (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward
CC       saturated C18 to C26 acyl-CoA substrates, with the highest activity
CC       towards C22:0 acyl-CoA. May participate to the production of both
CC       saturated and monounsaturated VLCFAs of different chain lengths that
CC       are involved in multiple biological processes as precursors of membrane
CC       lipids and lipid mediators. Important for saturated C24:0 and
CC       monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits
CC       @gn(RPE65) via production of VLCFAs.
else
CC   -!- FUNCTION: Catalyzes the first and rate-limiting reaction of the four
CC       reactions that constitute the long-chain fatty acids elongation cycle.
CC       This endoplasmic reticulum-bound enzymatic process allows the addition
CC       of 2 carbons to the chain of long- and very long-chain fatty acids
CC       (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward
CC       saturated C18 to C26 acyl-CoA substrates, with the highest activity
CC       towards C22:0 acyl-CoA. May participate to the production of both
CC       saturated and monounsaturated VLCFAs of different chain lengths that
CC       are involved in multiple biological processes as precursors of membrane
CC       lipids and lipid mediators.
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-
CC         chain 3-oxoacyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:32727,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57384, ChEBI:CHEBI:90725, ChEBI:CHEBI:90736;
CC         EC=2.3.1.199;
case <OC:Mammalia>
CC   -!- SUBUNIT: Interacts with @gn(LASS2), @gn(TECR) and @gn(HSD17B12).
end case
CC   -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC       membrane protein.
case <FTTag:ERmotif>
CC   -!- DOMAIN: The C-terminal di-lysine motif may confer endoplasmic reticulum
CC       localization.
end case
CC   -!- SIMILARITY: Belongs to the ELO family. ELOVL1 subfamily.
XX
DR   PROSITE; PS01188; ELO; 1; trigger=no
DR   Pfam; PF01151; ELO; 1; trigger=no
DR   General; Transmembrane; -; 7; trigger=yes
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KW   Endoplasmic reticulum
KW   Fatty acid biosynthesis
KW   Fatty acid metabolism
KW   Lipid biosynthesis
KW   Lipid metabolism
KW   Membrane
KW   Transferase
XX
GO   GO:0005789; C:endoplasmic reticulum membrane
GO   GO:0016020; C:membrane
GO   GO:0009922; F:fatty acid elongase activity
GO   GO:0006636; P:unsaturated fatty acid biosynthetic process
GO   GO:0019367; P:fatty acid elongation, saturated fatty acid
GO   GO:0034625; P:fatty acid elongation, monounsaturated fatty acid
GO   GO:0035338; P:long-chain fatty-acyl-CoA biosynthetic process
GO   GO:0042761; P:very long-chain fatty acid biosynthetic process
XX
FT   From: ELOV1_HUMAN (Q9BW60)
FT   MOTIF           Cter-4..Cter
FT                   /note="Di-lysine motif"
FT   Tag: ERmotif; Condition: K-x-K-x(2)>
XX
Size: 276-368;
Related: MF_03204; MF_03207;
Template: Q9BW60; Q9JLJ5;
Scope:
 Eukaryota; Vertebrata
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.14 2022/09/29
//