AC   MF_03202;
DC   Protein; auto
TR   HAMAP; MF_03202; -; 1; level=0
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Names: VLCF_elongase_2
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ID   ELOV2
DE   RecName: Full=Elongation of very long chain fatty acids protein 2;
DE            EC=2.3.1.199;
DE   AltName: Full=3-keto acyl-CoA synthase <gene_name>;
DE   AltName: Full=ELOVL fatty acid elongase 2;
DE            Short=ELOVL FA elongase 2;
DE   AltName: Full=Very long chain 3-ketoacyl-CoA synthase 2;
DE   AltName: Full=Very long chain 3-oxoacyl-CoA synthase 2;
GN   Name=ELOVL2;
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CC   -!- FUNCTION: Catalyzes the first and rate-limiting reaction of the four
CC       reactions that constitute the long-chain fatty acids elongation cycle.
CC       This endoplasmic reticulum-bound enzymatic process allows the addition
CC       of 2 carbons to the chain of long- and very long-chain fatty acids
CC       (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA
CC       with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme
CC       that catalyzes the synthesis of polyunsaturated very long chain fatty
CC       acid (C20- and C22-PUFA). May participate to the production of
CC       polyunsaturated VLCFAs of different chain lengths that are involved in
CC       multiple biological processes as precursors of membrane lipids and
CC       lipid mediators.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-
CC         chain 3-oxoacyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:32727,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57384, ChEBI:CHEBI:90725, ChEBI:CHEBI:90736;
CC         EC=2.3.1.199;
CC   -!- PATHWAY: Lipid metabolism; polyunsaturated fatty acid biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC       membrane protein.
case <FTTag:ERmotif>
CC   -!- DOMAIN: The C-terminal di-lysine motif may confer endoplasmic reticulum
CC       localization.
end case
CC   -!- SIMILARITY: Belongs to the ELO family. ELOVL2 subfamily.
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DR   PROSITE; PS01188; ELO; 1; trigger=no
DR   Pfam; PF01151; ELO; 1; trigger=no
DR   General; Transmembrane; -; 7; trigger=yes
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KW   Endoplasmic reticulum
KW   Fatty acid biosynthesis
KW   Fatty acid metabolism
KW   Lipid biosynthesis
KW   Lipid metabolism
KW   Membrane
KW   Transferase
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GO   GO:0005789; C:endoplasmic reticulum membrane
GO   GO:0016020; C:membrane
GO   GO:0009922; F:fatty acid elongase activity
GO   GO:0034626; P:fatty acid elongation, polyunsaturated fatty acid
GO   GO:0042761; P:very long-chain fatty acid biosynthetic process
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FT   From: ELOV2_HUMAN (Q9NXB9)
FT   MOTIF           Cter-3..Cter
FT                   /note="Di-lysine motif"
FT   Tag: ERmotif; Condition: K-K-x(2)>
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Size: 257-343;
Related: MF_03205;
Template: Q9NXB9; Q9JLJ4; D4A612;
Scope:
 Eukaryota; Vertebrata
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.12 2022/09/29
//