AC   MF_03205;
DC   Protein; auto
TR   HAMAP; MF_03205; -; 1; level=0
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Names: VLCF_elongase_5
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ID   ELOV5
DE   RecName: Full=Elongation of very long chain fatty acids protein 5;
DE            EC=2.3.1.199;
DE   AltName: Full=3-keto acyl-CoA synthase <gene_name>;
DE   AltName: Full=ELOVL fatty acid elongase 5;
DE            Short=ELOVL FA elongase 5;
DE   AltName: Full=Very long chain 3-ketoacyl-CoA synthase 5;
DE   AltName: Full=Very long chain 3-oxoacyl-CoA synthase 5;
GN   Name=ELOVL5;
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CC   -!- FUNCTION: Catalyzes the first and rate-limiting reaction of the four
CC       reactions that constitute the long-chain fatty acids elongation cycle.
CC       This endoplasmic reticulum-bound enzymatic process allows the addition
CC       of 2 carbons to the chain of long- and very long-chain fatty acids
CC       (VLCFAs) per cycle. Condensing enzyme that acts specifically toward
CC       polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6)
CC       acyl-CoA. May participate to the production of monounsaturated and of
CC       polyunsaturated VLCFAs of different chain lengths that are involved in
CC       multiple biological processes as precursors of membrane lipids and
CC       lipid mediators.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-
CC         chain 3-oxoacyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:32727,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57384, ChEBI:CHEBI:90725, ChEBI:CHEBI:90736;
CC         EC=2.3.1.199;
CC   -!- PATHWAY: Lipid metabolism; polyunsaturated fatty acid biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC       membrane protein. Cell projection, dendrite. Note=In Purkinje cells,
CC       the protein localizes to the soma and proximal portion of the dendritic
CC       tree.
CC   -!- SIMILARITY: Belongs to the ELO family. ELOVL5 subfamily.
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DR   PROSITE; PS01188; ELO; 1; trigger=no
DR   Pfam; PF01151; ELO; 1; trigger=no
DR   General; Transmembrane; -; 7; trigger=yes
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KW   Cell projection
KW   Endoplasmic reticulum
KW   Fatty acid biosynthesis
KW   Fatty acid metabolism
KW   Lipid biosynthesis
KW   Lipid metabolism
KW   Membrane
KW   Transferase
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GO   GO:0005789; C:endoplasmic reticulum membrane
GO   GO:0016020; C:membrane
GO   GO:0009922; F:fatty acid elongase activity
GO   GO:0034625; P:fatty acid elongation, monounsaturated fatty acid
GO   GO:0034626; P:fatty acid elongation, polyunsaturated fatty acid
GO   GO:0035338; P:long-chain fatty-acyl-CoA biosynthetic process
GO   GO:0006636; P:unsaturated fatty acid biosynthetic process
GO   GO:0042761; P:very long-chain fatty acid biosynthetic process
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Size: 269-300;
Related: MF_03202;
Template: Q2KJD9; Q920L7;
Scope:
 Eukaryota; Vertebrata
Fusion:
 Nter: None
 Cter: None
Duplicate: in SPETR
Plasmid: None
Comments: None
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# Revision 1.10 2022/09/29
//