AC MF_03206; DC Protein; auto TR HAMAP; MF_03206; -; 1; level=0 XX Names: VLCF_elongase_6 XX ID ELOV6 DE RecName: Full=Elongation of very long chain fatty acids protein 6; DE EC=2.3.1.199; DE AltName: Full=3-keto acyl-CoA synthase ; DE AltName: Full=ELOVL fatty acid elongase 6; DE Short=ELOVL FA elongase 6; DE AltName: Full=Very long chain 3-ketoacyl-CoA synthase 6; DE AltName: Full=Very long chain 3-oxoacyl-CoA synthase 6; GN Name=ELOVL6; XX CC -!- FUNCTION: Catalyzes the first and rate-limiting reaction of the four CC reactions that constitute the long-chain fatty acids elongation cycle. CC This endoplasmic reticulum-bound enzymatic process allows the addition CC of 2 carbons to the chain of long- and very long-chain fatty acids CC (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with CC 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. CC Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, CC to a lesser extent, C18:0 and those with low desaturation degree. May CC participate to the production of saturated and monounsaturated VLCFAs CC of different chain lengths that are involved in multiple biological CC processes as precursors of membrane lipids and lipid mediators. CC -!- CATALYTIC ACTIVITY: CC Reaction=a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long- CC chain 3-oxoacyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:32727, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, CC ChEBI:CHEBI:57384, ChEBI:CHEBI:90725, ChEBI:CHEBI:90736; CC EC=2.3.1.199; CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass CC membrane protein. case CC -!- DOMAIN: The C-terminal di-lysine motif may confer endoplasmic reticulum CC localization. end case CC -!- PTM: N-Glycosylated. CC -!- SIMILARITY: Belongs to the ELO family. ELOVL6 subfamily. XX DR PROSITE; PS00001; ASN_GLYCOSYLATION; 0-unlimited; trigger=yes DR PROSITE; PS01188; ELO; 1; trigger=no DR Pfam; PF01151; ELO; 1; trigger=no DR General; N_glycosylation; NetNGlyc; 0-unlimited; trigger=yes DR General; Transmembrane; -; 7; trigger=yes XX KW Endoplasmic reticulum KW Fatty acid biosynthesis KW Fatty acid metabolism KW Glycoprotein KW Lipid biosynthesis KW Lipid metabolism KW Membrane KW Transferase XX GO GO:0005789; C:endoplasmic reticulum membrane GO GO:0016020; C:membrane GO GO:0009922; F:fatty acid elongase activity GO GO:0006636; P:unsaturated fatty acid biosynthetic process GO GO:0019367; P:fatty acid elongation, saturated fatty acid GO GO:0034625; P:fatty acid elongation, monounsaturated fatty acid GO GO:0035338; P:long-chain fatty-acyl-CoA biosynthetic process XX FT From: ELOV6_HUMAN (Q9H5J4) FT MOTIF Cter-3..Cter FT /note="Di-lysine motif" FT Tag: ERmotif; Condition: K-x(2)-K> XX Size: 262-271; Related: MF_03203; Template: Q9H5J4; Q920L5; Q920L6; Scope: Eukaryota; Vertebrata Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.11 2022/09/29 //