AC   MF_03210;
DC   Protein; auto
TR   HAMAP; MF_03210; -; 1; level=0
XX
Names: Formate_dehydrogenase
XX
ID   FDH
case <OC:Viridiplantae>
DE   RecName: Full=Formate dehydrogenase, mitochondrial;
DE            Short=FDH;
DE            EC=1.17.1.9;
DE   AltName: Full=NAD-dependent formate dehydrogenase;
else
DE   RecName: Full=Formate dehydrogenase;
DE            Short=FDH;
DE            EC=1.17.1.9;
DE   AltName: Full=NAD-dependent formate dehydrogenase;
end case
XX
case <OC:Viridiplantae>
CC   -!- FUNCTION: Catalyzes the NAD(+)-dependent oxidation of formate to carbon
CC       dioxide. Involved in the cell stress response.
else
CC   -!- FUNCTION: Catalyzes the NAD(+)-dependent oxidation of formate to carbon
CC       dioxide. Formate oxidation is the final step in the methanol oxidation
CC       pathway in methylotrophic microorganisms. Has a role in the
CC       detoxification of exogenous formate in non-methylotrophic organisms.
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=formate + NAD(+) = CO2 + NADH; Xref=Rhea:RHEA:15985,
CC         ChEBI:CHEBI:15740, ChEBI:CHEBI:16526, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=1.17.1.9;
CC   -!- SUBUNIT: Homodimer.
case <OC:Viridiplantae>
CC   -!- SUBCELLULAR LOCATION: Mitochondrion.
else
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
end case
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. FDH subfamily.
case <OC:Viridiplantae> and not <AnyFeature:TransitM>
CC   -!- MISCELLANEOUS: This protein may be expected to contain an N-terminal
CC       transit peptide but none has been predicted.
end case
XX
DR   PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1; trigger=no
DR   PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1; trigger=no
DR   PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1; trigger=no
DR   Pfam; PF00389; 2-Hacid_dh; 1; trigger=no
DR   Pfam; PF02826; 2-Hacid_dh_C; 1; trigger=no
case <OC:Viridiplantae>
DR   General; TransitM; -; 0-1; trigger=yes
end case
XX
case <OC:Viridiplantae>
KW   Mitochondrion
else
KW   Cytoplasm
end case
KW   NAD
KW   Oxidoreductase
XX
case <OC:Viridiplantae>
GO   GO:0005739; C:mitochondrion
else
GO   GO:0005737; C:cytoplasm
end case
GO   GO:0008863; F:formate dehydrogenase (NAD+) activity
GO   GO:0042183; P:formate catabolic process
XX
FT   From: FDH_PSESR (P33160)
FT   BINDING         202..203
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: R-I
FT   BINDING         257..261
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: P-L-[HTY]-x(2)
FT   BINDING         333..336
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: H-x-S-G
FT   BINDING         123
FT                   /ligand="substrate"
FT   Condition: [IV]
FT   BINDING         147
FT                   /ligand="substrate"
FT   Condition: N
FT   BINDING         148
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Optional; Condition: [ST]
FT   BINDING         222
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: D
FT   BINDING         283
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: [TN]
FT   BINDING         309
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: D
FT   BINDING         381
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Optional; Condition: S
FT   SITE            285
FT                   /note="Important for catalytic activity"
FT   Condition: R
FT   SITE            333
FT                   /note="Important for catalytic activity"
FT   Condition: H
XX
Size: 341-402;
Related: None;
Template: P33160; O13437; Q08911; G0SGU4; Q07511; Q9S7E4;
Scope:
 Bacteria
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: in CANAL, ORYSJ, YEASC, YEAST
Plasmid: None
Comments: None
XX
# Revision 1.8 2022/11/19
//