AC   MF_03217;
DC   Protein; auto
TR   HAMAP; MF_03217; -; 1; level=0
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Names: PEMT
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ID   CHO2
DE   RecName: Full=Phosphatidylethanolamine N-methyltransferase;
DE            Short=PE methyltransferase;
DE            Short=PEAMT;
DE            Short=PEMT;
DE            EC=2.1.1.17;
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CC   -!- FUNCTION: Catalyzes the first step of the methylation pathway of
CC       phosphatidylcholine biosynthesis, the SAM-dependent methylation of
CC       phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine
CC       (PMME).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-
CC         methionine = 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine +
CC         H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:11164,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:64573, ChEBI:CHEBI:64612; EC=2.1.1.17;
CC   -!- PATHWAY: Phospholipid metabolism; phosphatidylcholine biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC       membrane protein.
CC   -!- SIMILARITY: Belongs to the class VI-like SAM-binding methyltransferase
CC       superfamily. CHO2 family.
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DR   PROSITE; PS51598; SAM_CHO2; 1; trigger=no
DR   PROSITE; PS50244; S5A_REDUCTASE; 0-1; trigger=no
DR   Pfam; PF04191; PEMT; 2; trigger=no
DR   PIRSF; PIRSF000383; PEAMT; 1; trigger=no
DR   General; Transmembrane; -; 11; trigger=strict
DR   ADD_TOPO_DOMAIN; Lumenal; -; 6; trigger=yes
DR   ADD_TOPO_DOMAIN; Cytoplasmic; -; 6; trigger=yes
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KW   Endoplasmic reticulum
KW   Lipid biosynthesis
KW   Lipid metabolism
KW   Membrane
KW   Methyltransferase
KW   Phospholipid biosynthesis
KW   Phospholipid metabolism
KW   S-adenosyl-L-methionine
KW   Transferase
KW   Transmembrane
KW   Transmembrane helix
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GO   GO:0005789; C:endoplasmic reticulum membrane
GO   GO:0004608; F:phosphatidylethanolamine N-methyltransferase activity
GO   GO:0006656; P:phosphatidylcholine biosynthetic process
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FT   None
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Size: 837-1077;
Related: None;
Template: P05374; Q7SAJ6;
Scope:
 Eukaryota; Fungi
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.4 2019/11/20
//