AC   MF_03222;
DC   Protein; auto
c?   <OC:Eukaryota>
TR   HAMAP; MF_01988; -; 1; level=0
XX
Names: Succ_CoA_alpha_euk
XX
ID   SUCA
case <OC:Metazoa> or <OC:Amoebozoa>
DE   RecName: Full=Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial;
DE            EC=6.2.1.4;
DE            EC=6.2.1.5;
DE   AltName: Full=Succinyl-CoA synthetase subunit alpha;
DE            Short=SCS-alpha;
else
DE   RecName: Full=Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial;
DE            EC=6.2.1.5;
DE   AltName: Full=Succinyl-CoA synthetase subunit alpha;
DE            Short=SCS-alpha;
end case
case <OC:Vertebrata>
GN   Name=SUCLG1;
end case
XX
case <OC:Metazoa> or <OC:Amoebozoa>
CC   -!- FUNCTION: Succinyl-CoA synthetase functions in the citric acid cycle
CC       (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of
CC       either ATP or GTP and thus represents the only step of substrate-level
CC       phosphorylation in the TCA. The alpha subunit of the enzyme binds the
CC       substrates coenzyme A and phosphate, while succinate binding and
CC       specificity for either ATP or GTP is provided by different beta
CC       subunits.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=CoA + GTP + succinate = GDP + phosphate + succinyl-CoA;
CC         Xref=Rhea:RHEA:22120, ChEBI:CHEBI:30031, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57292,
CC         ChEBI:CHEBI:58189; EC=6.2.1.4;
else
CC   -!- FUNCTION: Succinyl-CoA synthetase functions in the citric acid cycle
CC       (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP
CC       and thus represents the only step of substrate-level phosphorylation in
CC       the TCA. The alpha subunit of the enzyme binds the substrates coenzyme
CC       A and phosphate, while succinate binding and nucleotide specificity is
CC       provided by the beta subunit.
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + CoA + succinate = ADP + phosphate + succinyl-CoA;
CC         Xref=Rhea:RHEA:17661, ChEBI:CHEBI:30031, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57292,
CC         ChEBI:CHEBI:456216; EC=6.2.1.5;
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; succinate
CC       from succinyl-CoA (ligase route): step 1/1.
case <OC:Vertebrata>
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit. Different beta
CC       subunits determine nucleotide specificity. Together with the ATP-
CC       specific beta subunit @gn(SUCLA2), forms an ADP-forming succinyl-CoA
CC       synthetase (A-SCS). Together with the GTP-specific beta subunit
CC       @gn(SUCLG2) forms a GDP-forming succinyl-CoA synthetase (G-SCS).
else case <OC:Metazoa> or <OC:Amoebozoa>
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit. Different beta
CC       subunits determine nucleotide specificity. Together with an ATP-
CC       specific beta subunit, forms an ADP-forming succinyl-CoA synthetase (A-
CC       SCS). Together with a GTP-specific beta subunit forms a GDP-forming
CC       succinyl-CoA synthetase (G-SCS).
else
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit.
end case
CC   -!- SUBCELLULAR LOCATION: Mitochondrion.
CC   -!- SIMILARITY: Belongs to the succinate/malate CoA ligase alpha subunit
CC       family.
case not <AnyFeature:TransitM>
CC   -!- MISCELLANEOUS: This protein may be expected to contain an N-terminal
CC       transit peptide but none has been predicted.
end case
XX
DR   PROSITE; PS01216; SUCCINYL_COA_LIG_1; 1; trigger=no
DR   PROSITE; PS00399; SUCCINYL_COA_LIG_2; 1; trigger=no
DR   Pfam; PF02629; CoA_binding; 1; trigger=no
DR   Pfam; PF00549; Ligase_CoA; 1; trigger=no
DR   Pfam; PF13607; Succ_CoA_lig; 1; trigger=no
DR   PRINTS; PR01798; SCOASYNTHASE; 1; trigger=no
DR   NCBIfam; TIGR01019; sucCoAalpha; 1; trigger=no
DR   PIRSF; PIRSF001553; SucCS_alpha; 1; trigger=no
DR   General; TransitM; -; 0-1; trigger=yes
XX
KW   Ligase
KW   Mitochondrion
KW   Nucleotide-binding
KW   Tricarboxylic acid cycle
XX
GO   GO:0004775; F:succinate-CoA ligase (ADP-forming) activity
GO   GO:0006099; P:tricarboxylic acid cycle
XX
FT   From: SUCA_PIG (O19069)
FT   BINDING         64..67
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT   Condition: T-G-x(2)
FT   BINDING         143..145
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT   Condition: [IVL]-T-[ED]
FT   ACT_SITE        299
FT                   /note="Tele-phosphohistidine intermediate"
FT   Condition: H
FT   BINDING         90
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT   Condition: K
FT   BINDING         207
FT                   /ligand="substrate"
FT                   /ligand_note="ligand shared with subunit beta"
FT   Condition: Y
XX
Size: 299-347;
Related: None;
Template: O19069; Q9YGD2;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: in ARATH, SOLLC, TRIVA
Plasmid: None
Comments: None
XX
# Revision 1.8 2023/06/01
//