AC   MF_03226;
DC   Protein; auto
TR   HAMAP; MF_03226; -; 1; level=0
XX
Names: YJU2
XX
ID   YJU2
DE   RecName: Full=Splicing factor YJU2;
case <OC:Saccharomycetales> or <OC:Vertebrata>
GN   Name=YJU2;
end case
XX
case <OC:Saccharomycetales>
CC   -!- FUNCTION: Part of the spliceosome which catalyzes two sequential
CC       transesterification reactions, first the excision of the non-coding
CC       intron from pre-mRNA and then the ligation of the coding exons to form
CC       the mature mRNA. Plays a role (via N-terminus) in stabilizing the
CC       structure of the spliceosome catalytic core and docking of the branch
CC       helix into the active site, producing 5'-exon and lariat intron-3'-
CC       intermediates. Further stabilizes spliceosome conformation for 3'-
CC       splice site docking (via C-terminus) promoting exon ligation.
else case <OC:Vertebrata>
CC   -!- FUNCTION: Part of the spliceosome which catalyzes two sequential
CC       transesterification reactions, first the excision of the non-coding
CC       intron from pre-mRNA and then the ligation of the coding exons to form
CC       the mature mRNA. Plays a role in stabilizing the structure of the
CC       spliceosome catalytic core and docking of the branch helix into the
CC       active site, producing 5'-exon and lariat intron-3'-intermediates. May
CC       protect cells from TP53-dependent apoptosis upon dsDNA break damage
CC       through association with PRP19-CD5L complex.
else
CC   -!- FUNCTION: Part of the spliceosome which catalyzes two sequential
CC       transesterification reactions, first the excision of the non-coding
CC       intron from pre-mRNA and then the ligation of the coding exons to form
CC       the mature mRNA. Plays a role in stabilizing the structure of the
CC       spliceosome catalytic core and docking of the branch helix into the
CC       active site, producing 5'-exon and lariat intron-3'-intermediates.
end case
CC   -!- SUBUNIT: Component of the spliceosome. Present in the activated B
CC       complex, the catalytically activated B* complex which catalyzes the
CC       branching, the catalytic step 1 C complex catalyzing the exon ligation,
CC       and the postcatalytic P complex containing the ligated exons (mRNA) and
CC       the excised lariat intron.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the CWC16 family. YJU2 subfamily.
XX
DR   Pfam; PF04502; DUF572; 1; trigger=no
XX
KW   Nucleus
KW   Spliceosome
case <FTGroup:1>
KW   Metal-binding
KW   Zinc
end case
XX
GO   GO:0071006; C:U2-type catalytic step 1 spliceosome
GO   GO:0000349; P:generation of catalytic spliceosome for first transesterification step
case <OC:Saccharomycetales>
GO   GO:0071007; C:U2-type catalytic step 2 spliceosome
GO   GO:0000350; P:generation of catalytic spliceosome for second transesterification step
end case
XX
FT   From: YJU2_YEAST (P28320)
FT   BINDING         51
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         54
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         88
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         91
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
XX
Size: 270-345;
Related: None;
Template: P28320; Q9BW85; A8WHR3; Q9P7C5;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.6 2022/11/19
//