AC   MF_04002;
DC   Protein; auto
TR   HAMAP; MF_04002; -; 1; level=0
XX
Names: PPV_L1
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ID   VL1
DE   RecName: Full=Major capsid protein L1;
GN   Name=L1;
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CC   -!- FUNCTION: Forms an icosahedral capsid with a T=7 symmetry and a 50 nm
CC       diameter. The capsid is composed of 72 pentamers linked to each other
CC       by disulfide bonds and associated with L2 proteins. Binds to heparan
CC       sulfate proteoglycans on cell surface of basal layer keratinocytes to
CC       provide initial virion attachment. This binding mediates a
CC       conformational change in the virus capsid that facilitates efficient
CC       infection. The virion enters the host cell via endocytosis. During
CC       virus trafficking, L1 protein dissociates from the viral DNA and the
CC       genomic DNA is released to the host nucleus. The virion assembly takes
CC       place within the cell nucleus. Encapsulates the genomic DNA together
CC       with protein L2.
CC   -!- SUBUNIT: Self-assembles into homopentamers. The capsid has an
CC       icosahedral symmetry and consists of 72 capsomers, with each capsomer
CC       being a pentamer of L1. Interacts with the minor capsid protein L2;
CC       this interaction is necessary for viral genome encapsidation. Interacts
CC       with protein E2; this interaction enhances E2-dependent replication and
CC       transcription activation.
CC   -!- SUBCELLULAR LOCATION: Virion. Host nucleus.
CC   -!- SIMILARITY: Belongs to the papillomaviridae L1 protein family.
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DR   Pfam; PF00500; Late_protein_L1; 1; trigger=no
DR   PRINTS; PR00865; HPVCAPSIDL1; 1; trigger=no
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KW   Capsid protein
case <FTGroup:1>
KW   Disulfide bond
end case
KW   Host nucleus
KW   Host-virus interaction
KW   Late protein
KW   Viral attachment to host cell
KW   Viral penetration into host cytoplasm
KW   Virion
KW   Virus endocytosis by host
KW   Virus entry into host cell
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GO   GO:0042025; C:host cell nucleus
GO   GO:0039620; C:T=7 icosahedral viral capsid
GO   GO:0005198; F:structural molecule activity
GO   GO:0019062; P:virion attachment to host cell
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FT   From: VL1_HPV16 (P03101)
FT   DISULFID        175
FT                   /note="Interchain (with #{Cys-428})"
FT   Group: 1; Condition: C
FT   DISULFID        428
FT                   /note="Interchain (with #{Cys-175})"
FT   Group: 1; Condition: C
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Size: 494-568;
Related: None;
Template: P03101;
Scope:
 Viruses; Papillomaviridae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.6 2019/11/20
//